Manipulations of Redox Metabolism for Enhancing Radiation Therapy Responses: A Historical Perspective and Novel Hypothesis

Douglas R Spitz

doi:10.1016/j.semradonc.2018.10.010

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Manipulations of Redox Metabolism for Enhancing Radiation Therapy Responses: A Historical Perspective and Novel Hypothesis

Journal article

Peer reviewed

Manipulations of Redox Metabolism for Enhancing Radiation Therapy Responses: A Historical Perspective and Novel Hypothesis

Douglas R Spitz

Seminars in radiation oncology, Vol.29(1), pp.1-5

01/2019

DOI: 10.1016/j.semradonc.2018.10.010

PMCID: PMC6709524

PMID: 30573179

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Abstract

Since the recognition during the 20th century that cancer cells demonstrated fundamental alterations in the regulation of oxidative and glycolytic metabolism, many basic as well as translational scientists have proposed that targeting metabolic differences in cancer versus normal cells could be exploited to improve cancer therapy outcomes. With the recognition that dysregulation of mitochondrial redox metabolism leads to the increased steady-state levels of superoxide and hydrogen peroxide which could contribute to both aging and cancer; radiation biologists have pursued many avenues of targeting oxidative metabolic pathways to both selectively radiosensitive cancer cells as well as protect normal tissues during cancer therapy. Recent advances in exploiting redox metabolism for improving radiochemotherapy both from a basic and translational science point of view are the focus of the papers in this current issue of Seminars in Radiation Oncology. The historical perspective underlying these areas of research as well as a unifying hypothesis for further advancing this research into clinical trials will be presented in this overview.

Signal Transduction

Neoplasms - metabolism

Antioxidants - therapeutic use

Neoplasms - therapy

Humans

Gene Expression Regulation, Neoplastic

Oxidation-Reduction - drug effects

Oxidation-Reduction - radiation effects

Oxidative Stress - radiation effects

Oxidative Stress - drug effects

Chemoradiotherapy

Details

Title: Subtitle: Manipulations of Redox Metabolism for Enhancing Radiation Therapy Responses: A Historical Perspective and Novel Hypothesis
Creators: Douglas R Spitz - Free Radical and Radiation Biology Program, Department of Radiation Oncology, Free Radical Metabolism and Imaging Program, Holden Comprehensive Cancer Center, B180 Medical Laboratories, Carver College of Medicine, The University of Iowa, Iowa City, IA 52242.. Electronic address: douglas-spitz@uiowa.edu
Resource Type: Journal article
Publication Details: Seminars in radiation oncology, Vol.29(1), pp.1-5
DOI: 10.1016/j.semradonc.2018.10.010
PMID: 30573179
PMCID: PMC6709524
NLM abbreviation: Semin Radiat Oncol
ISSN: 1053-4296
eISSN: 1532-9461
Publisher: United States
Grant note: P01 CA217797 / NCI NIH HHS P30 CA086862 / NCI NIH HHS R01 CA182804 / NCI NIH HHS
Language: English
Date published: 01/2019
Academic Unit: Pathology; Radiation Oncology
Record Identifier: 9984047621202771

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