Mannitol bolus preferentially shrinks non-infarcted brain in patients with ischemic stroke

T. O VIDEEN; A. R ZAZULIA; E. M MANNO; C. P DERDEYN; R. E ADAMS; M. N DIRINGER; W. J POWERS

doi:10.1212/WNL.57.11.2120

Back

Mannitol bolus preferentially shrinks non-infarcted brain in patients with ischemic stroke

Journal article

Peer reviewed

Mannitol bolus preferentially shrinks non-infarcted brain in patients with ischemic stroke

T. O VIDEEN, A. R ZAZULIA, E. M MANNO, C. P DERDEYN, R. E ADAMS, M. N DIRINGER and W. J POWERS

Neurology, Vol.57(11), pp.2120-2122

2001

DOI: 10.1212/WNL.57.11.2120

PMID: 11739839

View Online

Abstract

Changes in brain tissue volume in six patients who had acute complete middle cerebral artery (MCA) infarctions and CT evidence of midline shift were measured using the brain boundary shift integral (BBSI) on sequential T1-weighted MR images acquired before and after a 1.5-g/kg bolus infusion of mannitol. At 50 to 55 minutes after the baseline scan, total brain volume decreased by 8.1 ± 2.8 mL (0.6%, p < 0.005). Brain in the noninfarcted hemisphere shrank more (0.8 ± 0.4%) than in the infarcted hemisphere (0.0 ± 0.5%, p < 0.05).

Neuropharmacology

Biological and medical sciences

Miscellaneous

Medical sciences

Pharmacology. Drug treatments

Details

Title: Subtitle: Mannitol bolus preferentially shrinks non-infarcted brain in patients with ischemic stroke
Creators: T. O VIDEEN - Department of Neurology and Neurological Surgery, Washington University School of Medicine, St. Louis, MO, United States
A. R ZAZULIA - Department of Neurology and Neurological Surgery, Washington University School of Medicine, St. Louis, MO, United States
E. M MANNO - Department of Neurology and Neurological Surgery, Washington University School of Medicine, St. Louis, MO, United States
C. P DERDEYN - Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, United States
R. E ADAMS - Department of Neurology and Neurological Surgery, Washington University School of Medicine, St. Louis, MO, United States
M. N DIRINGER - Department of Neurology and Neurological Surgery, Washington University School of Medicine, St. Louis, MO, United States
W. J POWERS - Department of Neurology and Neurological Surgery, Washington University School of Medicine, St. Louis, MO, United States
Resource Type: Journal article
Publication Details: Neurology, Vol.57(11), pp.2120-2122
Publisher: Lippincott Williams & Wilkins; Hagerstown, MD
DOI: 10.1212/WNL.57.11.2120
PMID: 11739839
ISSN: 0028-3878
eISSN: 1526-632X
Language: English
Date published: 2001
Academic Unit: Neurology; Radiology; Iowa Neuroscience Institute; Neurosurgery
Record Identifier: 9984020886902771

Metrics

12 Record Views

70 Times Cited - Web of Science

See more details