Journal article
Mannitol-coated hydroxypropyl methylcellulose as an alternative directly compressible controlled release excipient
International journal of pharmaceutics, Vol.660, 124298
07/2024
DOI: 10.1016/j.ijpharm.2024.124298
PMID: 38825172
Abstract
One of the most common forms of controlled release technology for oral drug delivery comprises an active ingredient dispersed in a hydrophilic matrix forming polymer such as hydroxypropyl methylcellulose (HPMC), which is tableted via direct compression. However, HPMC may pose problems in direct compression due to its poor flowability. Hence, mannitol syrup was spray-coated over fluidized HPMC particles to produce co-processed HPMC-mannitol at ratios of 20:80, 50:50, and 70:30. Particles of pure HPMC, co-processed HPMC-mannitol, and respective physical mixtures were evaluated for powder flowability, compression profiles, and controlled release performance. It was found that co-processed HPMC-mannitol consisted of particles with improved flow compared to pure HPMC particles. Sufficiently strong tablets of >2 MPa could be produced at moderate to high compression forces of 150-200 MPa. The dissolution profile could be tuned to obtain desired release profiles by altering HPMC-mannitol ratios. Co-processed HPMC-mannitol offers an interesting addition to the formulator's toolbox in the design of controlled release formulations for direct compression.
Details
- Title: Subtitle
- Mannitol-coated hydroxypropyl methylcellulose as an alternative directly compressible controlled release excipient
- Creators
- Christina Yong Xin Kang - National University of SingaporeWen Chin Foo - BiopolisKwan Hang Lam - BiopolisKeat Theng Chow - BiopolisYuan Siang Lui - BiopolisHui Ping Goh - BiopolisAntoine Salome - Roquette Frères, 1 rue de la Haute Loge, Lestrem 62136, FranceBaptiste Boit - Roquette FrèresPhilippe Lefevre - Roquette FrèresTze Ning Hiew - University of IowaRajeev Gokhale - Roquette America Inc., 2211 Innovation Drive, Geneva, IL 60134, USA. Electronic address: rajeev.gokhale@roquette.comPaul Wan Sia Heng - Airlangga University
- Resource Type
- Journal article
- Publication Details
- International journal of pharmaceutics, Vol.660, 124298
- DOI
- 10.1016/j.ijpharm.2024.124298
- PMID
- 38825172
- eISSN
- 1873-3476
- Language
- English
- Electronic publication date
- 05/31/2024
- Date published
- 07/2024
- Academic Unit
- Pharmaceutical Sciences and Experimental Therapeutics
- Record Identifier
- 9984635156302771
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