Journal article
Manual and Automated Measurement of the Whole Thalamus and Mediodorsal Nucleus Using Magnetic Resonance Imaging
NeuroImage (Orlando, Fla.), Vol.17(2), pp.631-642
2002
DOI: 10.1006/nimg.2002.1185
PMID: 12377139
Abstract
The thalamus is an important relay structure in the brain that may be relevant to a variety of brain diseases. It is divided into multiple subnuclei with different cortical connections. The medial dorsal (MD) nucleus is particularly important because it forms key connections with the prefrontal cortex. The current study reports precise and efficient methods for measuring the whole thalamus and the MD with MRI that have a high degree of interrater reliability. A multispectral image acquisition and novel image processing technique were used to improve structure visibility. The tricolor image assigns a color to each of the T1, T2, and PD weighted images, represented by red, green, and blue, respectively. The manually defined regions were then used to train an artificial neural network (ANN) to automatically define both the whole thalamus and the MD. The ANN provides an efficient automated method, making studies using larger sample sizes more feasible.
Details
- Title: Subtitle
- Manual and Automated Measurement of the Whole Thalamus and Mediodorsal Nucleus Using Magnetic Resonance Imaging
- Creators
- Ruth Spinks - Mental Health–Clinical Research Center, University of Iowa College of Medicine, University of Iowa, Iowa City, Iowa, 52242Vincent A Magnotta - Mental Health–Clinical Research Center, University of Iowa College of Medicine, University of Iowa, Iowa City, Iowa, 52242Nancy C Andreasen - Mental Health–Clinical Research Center, University of Iowa College of Medicine, University of Iowa, Iowa City, Iowa, 52242Karen C Albright - Mental Health–Clinical Research Center, University of Iowa College of Medicine, University of Iowa, Iowa City, Iowa, 52242Steven Ziebell - Mental Health–Clinical Research Center, University of Iowa College of Medicine, University of Iowa, Iowa City, Iowa, 52242Peggy Nopoulos - Department of Psychiatry, University of Iowa College of Medicine, University of Iowa, Iowa City, Iowa, 52242Martin Cassell - Department of Anatomy, University of Iowa College of Medicine, University of Iowa, Iowa City, Iowa, 52242
- Resource Type
- Journal article
- Publication Details
- NeuroImage (Orlando, Fla.), Vol.17(2), pp.631-642
- Publisher
- Elsevier Inc
- DOI
- 10.1006/nimg.2002.1185
- PMID
- 12377139
- ISSN
- 1053-8119
- eISSN
- 1095-9572
- Language
- English
- Date published
- 2002
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Neurology; Radiology; Psychiatry; Anatomy and Cell Biology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute
- Record Identifier
- 9984003453402771
Metrics
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