Journal article
Mapping Alveolar Oxygen Partial Pressure in COPD Using Hyperpolarized Helium-3: The Multi-Ethnic Study of Atherosclerosis (MESA) COPD Study
Tomography (Ann Arbor), Vol.8(5), pp.2268-2284
09/13/2022
DOI: 10.3390/tomography8050190
PMCID: PMC9498778
PMID: 36136886
Abstract
Chronic obstructive pulmonary disease (COPD) and emphysema are characterized by functional and structural damage which increases the spaces for gaseous diffusion and impairs oxygen exchange. Here we explore the potential for hyperpolarized (HP)
3
He MRI to characterize lung structure and function in a large-scale population-based study. Participants (
n
= 54) from the Multi-Ethnic Study of Atherosclerosis (MESA) COPD Study, a nested case-control study of COPD among participants with 10+ packyears underwent HP
3
He MRI measuring p
A
O
2
, apparent diffusion coefficient (ADC), and ventilation. HP MRI measures were compared to full-lung CT and pulmonary function testing. High ADC values (>0.4 cm
2
/s) correlated with emphysema and heterogeneity in p
A
O
2
measurements. Strong correlations were found between the heterogeneity of global p
A
O
2
as summarized by its standard deviation (SD) (
p
< 0.0002) and non-physiologic p
A
O
2
values (
p
< 0.0001) with percent emphysema on CT. A regional study revealed a strong association between p
A
O
2
SD and visual emphysema severity (
p
< 0.003) and an association with the paraseptal emphysema subtype (
p
< 0.04) after adjustment for demographics and smoking status. HP noble gas p
A
O
2
heterogeneity and the fraction of non-physiological p
A
O
2
results increase in mild to moderate COPD. Measurements of p
A
O
2
are sensitive to regional emphysematous damage detected by CT and may be used to probe pulmonary emphysema subtypes. HP noble gas lung MRI provides non-invasive information about COPD severity and lung function without ionizing radiation.
Details
- Title: Subtitle
- Mapping Alveolar Oxygen Partial Pressure in COPD Using Hyperpolarized Helium-3: The Multi-Ethnic Study of Atherosclerosis (MESA) COPD Study
- Creators
- Naz P. Taskiran - Department of Chemical Engineering, Columbia University, New York, NY 10027, USA Division of General Medicine, Columbia University Irving Medial Center, New York, NY 10032, USA Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA Neurological Institute, Radiology, Columbia University, New York, NY 10032, USA Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA Mailman School of Public Health, Columbia University, New York, NY 10032, USA Department of Radiology, Weill Cornell Medicine, New York, NY 10065, USA Department of Medicine, McGill University, Montreal, QC H3G 2M1, Canada Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield S10 2TN, UK Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Columbia University Irving Medical Center, New York, NY 10032, USA Institute of Human Nutrition, College of Physicians & Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA Columbia Magnetic Resonance Research Center (CMRRC), Columbia University, New York, NY 10027, USA Department of Physics, Columbia University, New York, NY 10027, USAGrant T. Hiura - Department of Chemical Engineering, Columbia University, New York, NY 10027, USA Division of General Medicine, Columbia University Irving Medial Center, New York, NY 10032, USA Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA Neurological Institute, Radiology, Columbia University, New York, NY 10032, USA Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA Mailman School of Public Health, Columbia University, New York, NY 10032, USA Department of Radiology, Weill Cornell Medicine, New York, NY 10065, USA Department of Medicine, McGill University, Montreal, QC H3G 2M1, Canada Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield S10 2TN, UK Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Columbia University Irving Medical Center, New York, NY 10032, USA Institute of Human Nutrition, College of Physicians & Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA Columbia Magnetic Resonance Research Center (CMRRC), Columbia University, New York, NY 10027, USA Department of Physics, Columbia University, New York, NY 10027, USAXuzhe Zhang - Department of Chemical Engineering, Columbia University, New York, NY 10027, USA Division of General Medicine, Columbia University Irving Medial Center, New York, NY 10032, USA Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA Neurological Institute, Radiology, Columbia University, New York, NY 10032, USA Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA Mailman School of Public Health, Columbia University, New York, NY 10032, USA Department of Radiology, Weill Cornell Medicine, New York, NY 10065, USA Department of Medicine, McGill University, Montreal, QC H3G 2M1, Canada Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield S10 2TN, UK Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Columbia University Irving Medical Center, New York, NY 10032, USA Institute of Human Nutrition, College of Physicians & Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA Columbia Magnetic Resonance Research Center (CMRRC), Columbia University, New York, NY 10027, USA Department of Physics, Columbia University, New York, NY 10027, USAR. Graham Barr - University of IowaStephen M. Dashnaw - Department of Chemical Engineering, Columbia University, New York, NY 10027, USA Division of General Medicine, Columbia University Irving Medial Center, New York, NY 10032, USA Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA Neurological Institute, Radiology, Columbia University, New York, NY 10032, USA Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA Mailman School of Public Health, Columbia University, New York, NY 10032, USA Department of Radiology, Weill Cornell Medicine, New York, NY 10065, USA Department of Medicine, McGill University, Montreal, QC H3G 2M1, Canada Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield S10 2TN, UK Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Columbia University Irving Medical Center, New York, NY 10032, USA Institute of Human Nutrition, College of Physicians & Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA Columbia Magnetic Resonance Research Center (CMRRC), Columbia University, New York, NY 10027, USA Department of Physics, Columbia University, New York, NY 10027, USAEric A. Hoffman - University of IowaDaniel Malinsky - Department of Chemical Engineering, Columbia University, New York, NY 10027, USA Division of General Medicine, Columbia University Irving Medial Center, New York, NY 10032, USA Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA Neurological Institute, Radiology, Columbia University, New York, NY 10032, USA Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA Mailman School of Public Health, Columbia University, New York, NY 10032, USA Department of Radiology, Weill Cornell Medicine, New York, NY 10065, USA Department of Medicine, McGill University, Montreal, QC H3G 2M1, Canada Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield S10 2TN, UK Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Columbia University Irving Medical Center, New York, NY 10032, USA Institute of Human Nutrition, College of Physicians & Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA Columbia Magnetic Resonance Research Center (CMRRC), Columbia University, New York, NY 10027, USA Department of Physics, Columbia University, New York, NY 10027, USAElizabeth C. Oelsner - Department of Chemical Engineering, Columbia University, New York, NY 10027, USA Division of General Medicine, Columbia University Irving Medial Center, New York, NY 10032, USA Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA Neurological Institute, Radiology, Columbia University, New York, NY 10032, USA Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA Mailman School of Public Health, Columbia University, New York, NY 10032, USA Department of Radiology, Weill Cornell Medicine, New York, NY 10065, USA Department of Medicine, McGill University, Montreal, QC H3G 2M1, Canada Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield S10 2TN, UK Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Columbia University Irving Medical Center, New York, NY 10032, USA Institute of Human Nutrition, College of Physicians & Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA Columbia Magnetic Resonance Research Center (CMRRC), Columbia University, New York, NY 10027, USA Department of Physics, Columbia University, New York, NY 10027, USAMartin R. Prince - University of IowaBenjamin M. Smith - University of IowaYanping Sun - Department of Chemical Engineering, Columbia University, New York, NY 10027, USA Division of General Medicine, Columbia University Irving Medial Center, New York, NY 10032, USA Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA Neurological Institute, Radiology, Columbia University, New York, NY 10032, USA Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA Mailman School of Public Health, Columbia University, New York, NY 10032, USA Department of Radiology, Weill Cornell Medicine, New York, NY 10065, USA Department of Medicine, McGill University, Montreal, QC H3G 2M1, Canada Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield S10 2TN, UK Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Columbia University Irving Medical Center, New York, NY 10032, USA Institute of Human Nutrition, College of Physicians & Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA Columbia Magnetic Resonance Research Center (CMRRC), Columbia University, New York, NY 10027, USA Department of Physics, Columbia University, New York, NY 10027, USAYifei Sun - University of IowaJim M. Wild - University of IowaWei Shen - University of IowaEmlyn W. Hughes - Department of Chemical Engineering, Columbia University, New York, NY 10027, USA Division of General Medicine, Columbia University Irving Medial Center, New York, NY 10032, USA Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA Neurological Institute, Radiology, Columbia University, New York, NY 10032, USA Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA Mailman School of Public Health, Columbia University, New York, NY 10032, USA Department of Radiology, Weill Cornell Medicine, New York, NY 10065, USA Department of Medicine, McGill University, Montreal, QC H3G 2M1, Canada Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield S10 2TN, UK Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Columbia University Irving Medical Center, New York, NY 10032, USA Institute of Human Nutrition, College of Physicians & Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA Columbia Magnetic Resonance Research Center (CMRRC), Columbia University, New York, NY 10027, USA Department of Physics, Columbia University, New York, NY 10027, USA
- Resource Type
- Journal article
- Publication Details
- Tomography (Ann Arbor), Vol.8(5), pp.2268-2284
- DOI
- 10.3390/tomography8050190
- PMID
- 36136886
- PMCID
- PMC9498778
- NLM abbreviation
- Tomography
- ISSN
- 2379-1381
- eISSN
- 2379-139X
- Publisher
- MDPI
- Grant note
- R01-HL093081; R01-HL077612; R01-HL121270 / National Institutes of Health/National Heart, Lung, and Blood Institute UL1-TR-000040; UL1-TR-001079; UL1-TR-001420 / National Center for Advancing Translational Sciences 75N92020D00001; HHSN268201500003I; N01-HC-95159; 75N92020D00005; N01-HC-95160; 75N92020D00002; N01-HC-95161; 75N92020D00003; N01-HC-95162; 75N92020D00006; N01-HC-95163; 75N92020D00004; N01-HC-95164; 75N92020D00007; N01-HC-95165; N01-HC-95166; N01-HC-95167; N01-HC-95168; N01-HC-95169 / National Heart, Lung, and Blood Institute
- Language
- English
- Date published
- 09/13/2022
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Internal Medicine
- Record Identifier
- 9984318790602771
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