Mapping cortical brain asymmetry in 17,141 healthy individuals worldwide via the ENIGMA Consortium

Xiang-Zhen Kong; Samuel R Mathias; Tulio Guadalupe; David C Glahn; Barbara Franke; Fabrice Crivello; Nathalie Tzourio-Mazoyer; Simon E Fisher; Paul M Thompson; Clyde Francks; ENIGMA Laterality Working Group

doi:10.1073/pnas.1718418115

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Mapping cortical brain asymmetry in 17,141 healthy individuals worldwide via the ENIGMA Consortium

Journal article

Open access

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Mapping cortical brain asymmetry in 17,141 healthy individuals worldwide via the ENIGMA Consortium

Xiang-Zhen Kong, Samuel R Mathias, Tulio Guadalupe, David C Glahn, Barbara Franke, Fabrice Crivello, Nathalie Tzourio-Mazoyer, Simon E Fisher, Paul M Thompson, Clyde Francks, …

Proceedings of the National Academy of Sciences - PNAS, Vol.115(22), pp.E5154-E5163

05/29/2018

DOI: 10.1073/pnas.1718418115

PMCID: PMC5984496

PMID: 29764998

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Abstract

Hemispheric asymmetry is a cardinal feature of human brain organization. Altered brain asymmetry has also been linked to some cognitive and neuropsychiatric disorders. Here, the ENIGMA (Enhancing NeuroImaging Genetics through Meta-Analysis) Consortium presents the largest-ever analysis of cerebral cortical asymmetry and its variability across individuals. Cortical thickness and surface area were assessed in MRI scans of 17,141 healthy individuals from 99 datasets worldwide. Results revealed widespread asymmetries at both hemispheric and regional levels, with a generally thicker cortex but smaller surface area in the left hemisphere relative to the right. Regionally, asymmetries of cortical thickness and/or surface area were found in the inferior frontal gyrus, transverse temporal gyrus, parahippocampal gyrus, and entorhinal cortex. These regions are involved in lateralized functions, including language and visuospatial processing. In addition to population-level asymmetries, variability in brain asymmetry was related to sex, age, and intracranial volume. Interestingly, we did not find significant associations between asymmetries and handedness. Finally, with two independent pedigree datasets ( = 1,443 and 1,113, respectively), we found several asymmetries showing significant, replicable heritability. The structural asymmetries identified and their variabilities and heritability provide a reference resource for future studies on the genetic basis of brain asymmetry and altered laterality in cognitive, neurological, and psychiatric disorders.

Adolescent

Adult

Aged

Aged, 80 and over

Cerebral Cortex - diagnostic imaging

Child

Child, Preschool

Databases, Factual - statistics & numerical data

Female

Humans

Infant

Male

Middle Aged

Neuroimaging - methods

Young Adult

Details

Title: Subtitle: Mapping cortical brain asymmetry in 17,141 healthy individuals worldwide via the ENIGMA Consortium
Creators: Xiang-Zhen Kong
Samuel R Mathias - Yale University
Tulio Guadalupe - Max Planck Society
David C Glahn - Yale University
Barbara Franke - Donders Institute for Brain, Cognition and Behaviour, External Organizations
Fabrice Crivello - Commissariat à l'Énergie Atomique et aux Énergies Alternatives
Nathalie Tzourio-Mazoyer - Commissariat à l'Énergie Atomique et aux Énergies Alternatives
Simon E Fisher - Max Planck Society
Paul M Thompson - University of Southern California
Clyde Francks - Max Planck Society
ENIGMA Laterality Working Group
Contributors: Beng Choon Ho (Contributor) - University of Iowa, Psychiatry
Resource Type: Journal article
Publication Details: Proceedings of the National Academy of Sciences - PNAS, Vol.115(22), pp.E5154-E5163
DOI: 10.1073/pnas.1718418115
PMID: 29764998
PMCID: PMC5984496
NLM abbreviation: Proc Natl Acad Sci U S A
ISSN: 0027-8424
eISSN: 1091-6490
Publisher: National Academy of Sciences
Grant note: P20 DA022539 / NIDA NIH HHS R00 MH091238 / NIMH NIH HHS R01 MH115357 / NIMH NIH HHS P50 DA016556 / NIDA NIH HHS P20 RR021938 / NCRR NIH HHS R01 MH085734 / NIMH NIH HHS U24 RR021992 / NCRR NIH HHS G0500092 / Medical Research Council P20 GM103472 / NIGMS NIH HHS R01 MH117107 / NIMH NIH HHS K99 AA025401 / NIAAA NIH HHS R56 MH086654 / NIMH NIH HHS R01 MH086654 / NIMH NIH HHS UL1 DE019586 / NIDCR NIH HHS R01 AA013892 / NIAAA NIH HHS R01 DA018307 / NIDA NIH HHS R01 MH099064 / NIMH NIH HHS R01 EB006841 / NIBIB NIH HHS T32 DA022975 / NIDA NIH HHS Biotechnology and Biological Sciences Research Council R01 EB005846 / NIBIB NIH HHS R01 MH096773 / NIMH NIH HHS RC1 MH089257 / NIMH NIH HHS U54 EB020403 / NIBIB NIH HHS R01 DA015179 / NIDA NIH HHS 500236/Z/11/Z / Wellcome Trust MC_UU_00011/5 / Medical Research Council R01 MH094524 / NIMH NIH HHS R01 DA020726 / NIDA NIH HHS PL1 DA024859 / NIDA NIH HHS G1001245 / Medical Research Council K08 MH068540 / NIMH NIH HHS HHSN271200800009C / NIDA NIH HHS UL1 TR000128 / NCATS NIH HHS MR/K026992/1 / Medical Research Council R01 DA014100 / NIDA NIH HHS R01 EB000840 / NIBIB NIH HHS G0701120 / Medical Research Council
Language: English
Date published: 05/29/2018
Academic Unit: Psychiatry
Record Identifier: 9984280878002771

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