Journal article
Mapping of the human complement factor I gene to 4q25
Genomics (San Diego, Calif.), Vol.4(1), pp.82-86
1989
DOI: 10.1016/0888-7543(89)90318-2
PMID: 2563353
Abstract
A detailed genetic and physical map of human complement factor I (IF) using somatic cell hybrids,
in situ hybridization, and genetic linkage is reported. The gene has been localized to band 4q25. The order GC-INP10-ADH3-EGF-IF-IL2-MNS is proposed for genes on 4q on the basis of genetic and physical mapping techniques. A
BclI polymorphism found with the IF probe demonstrated a maternal origin for a
de novo deletion of chromosome 4 that was used in physically mapping the gene. The genetic and physical distances around band 4q24 suggest that 1 cM is approximately 1.2 million bp of DNA. This work provides a useful addition to the map of 4q.
Details
- Title: Subtitle
- Mapping of the human complement factor I gene to 4q25
- Creators
- Rita Shiang - Department of Pediatrics, University of Iowa, Iowa City, Iowa 52242 USAJeffrey C Murray - Department of Pediatrics, University of Iowa, Iowa City, Iowa 52242 USACynthia C Morton - Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115 USAKenneth H Buetow - Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111 USAJohn J Wasmuth - Department of Biological Chemistry, University of California, Irvine, California 92717 USAAnn Haskins Olney - Department of Pediatrics, University of Nebraska, Lincoln, Nebraska 68105 USAWarren G Sanger - Department of Pediatrics, University of Nebraska, Lincoln, Nebraska 68105 USAGabriel Goldberger - Laboratory of Human Biochemistry, Department of Medicine, Children's Hospital Corporation, Boston, Massachusetts 02115 USA
- Resource Type
- Journal article
- Publication Details
- Genomics (San Diego, Calif.), Vol.4(1), pp.82-86
- DOI
- 10.1016/0888-7543(89)90318-2
- PMID
- 2563353
- NLM abbreviation
- Genomics
- ISSN
- 0888-7543
- eISSN
- 1089-8646
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 1989
- Academic Unit
- Anatomy and Cell Biology; Stead Family Department of Pediatrics; Epidemiology; Pediatric Dentistry; Craniofacial Anomalies Research Center; Dental Research
- Record Identifier
- 9984025579502771
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