Mapping the effect of drugs on ACE2 as a novel target site for COVID-19 therapy

H. F. Hetta; K. Muhammad; A. M. Algammal; H. Ramadan; M. S. Abdel-Rahman; M. Mabrok; G. Koneru; A. A. Elkady; G. El-Saber Batiha; Y. Waheed; N. Munawar; H. S. M. Farghaly

doi:10.26355/eurrev_202105_25963

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Mapping the effect of drugs on ACE2 as a novel target site for COVID-19 therapy

Journal article

Peer reviewed

Mapping the effect of drugs on ACE2 as a novel target site for COVID-19 therapy

H. F. Hetta, K. Muhammad, A. M. Algammal, H. Ramadan, M. S. Abdel-Rahman, M. Mabrok, G. Koneru, A. A. Elkady, G. El-Saber Batiha, Y. Waheed, …

European review for medical and pharmacological sciences, Vol.25(10), pp.3923-3932

01/01/2021

DOI: 10.26355/eurrev_202105_25963

PMID: 34109607

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Abstract

Angiotensin converting enzyme 2 (ACE2) has potentially conflicting roles in health and disease. COVID-19 coronavirus binds to human cells via ACE2 receptor, which is expressed on almost all body organs. Boosting the ACE2 receptor levels on heart and lung cells may provide more cellular enter to virus thereby worsening the infection. Therefore, among the drug targets, ACE2 is suggested as a vital target of COVID-19 therapy. This hypothesis is based on the protective role of the drugs acting on ACE2. Therefore, this review discusses the impact and challenges of using ACE2 as a target in the current therapy of COVID-19.

Life Sciences & Biomedicine

Pharmacology & Pharmacy

Science & Technology

Details

Title: Subtitle: Mapping the effect of drugs on ACE2 as a novel target site for COVID-19 therapy
Creators: H. F. Hetta - University of Cincinnati Medical Center
K. Muhammad - United Arab Emirates University
A. M. Algammal - Suez Canal University
H. Ramadan - USDADARS, Bacterial Epidemiol & Antimicrobial Resistance R, Us Natl Poultry Res Ctr, Athens, GA USA
M. S. Abdel-Rahman - Assiut University
M. Mabrok - Suez Canal University
G. Koneru - Rutgers State Univ, Rutger New Jersey Med Sch, Dept Med, Div Gastroenterol & Hepatol, New Brunswick, NJ USA
A. A. Elkady - Sohag University
G. El-Saber Batiha - Damanhour University
Y. Waheed - Foundation University Islamabad
N. Munawar - United Arab Emirates University
H. S. M. Farghaly - Assiut University
Resource Type: Journal article
Publication Details: European review for medical and pharmacological sciences, Vol.25(10), pp.3923-3932
Publisher: Verduci Publisher
DOI: 10.26355/eurrev_202105_25963
PMID: 34109607
ISSN: 1128-3602
eISSN: 2284-0729
Number of pages: 10
Language: English
Date published: 01/01/2021
Academic Unit: Internal Medicine
Record Identifier: 9984359664802771

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