Mapping the genetic variation of regional brain volumes as explained by all common SNPs from the ADNI study

Christopher Bryant; Kelly S Giovanello; Joseph G Ibrahim; Jing Chang; Dinggang Shen; Bradley S Peterson; Hongtu Zhu; Alzheimer's Disease Neuroimaging Initiative

doi:10.1371/journal.pone.0071723

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Mapping the genetic variation of regional brain volumes as explained by all common SNPs from the ADNI study

Journal article

Open access

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Mapping the genetic variation of regional brain volumes as explained by all common SNPs from the ADNI study

Christopher Bryant, Kelly S Giovanello, Joseph G Ibrahim, Jing Chang, Dinggang Shen, Bradley S Peterson, Hongtu Zhu and Alzheimer's Disease Neuroimaging Initiative

PloS one, Vol.8(8), pp.e71723-e71723

2013

DOI: 10.1371/journal.pone.0071723

PMCID: PMC3756017

PMID: 24015190

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Abstract

Typically twin studies are used to investigate the aggregate effects of genetic and environmental influences on brain phenotypic measures. Although some phenotypic measures are highly heritable in twin studies, SNPs (single nucleotide polymorphisms) identified by genome-wide association studies (GWAS) account for only a small fraction of the heritability of these measures. We mapped the genetic variation (the proportion of phenotypic variance explained by variation among SNPs) of volumes of pre-defined regions across the whole brain, as explained by 512,905 SNPs genotyped on 747 adult participants from the Alzheimer's Disease Neuroimaging Initiative (ADNI). We found that 85% of the variance of intracranial volume (ICV) (p = 0.04) was explained by considering all SNPs simultaneously, and after adjusting for ICV, total grey matter (GM) and white matter (WM) volumes had genetic variation estimates near zero (p = 0.5). We found varying estimates of genetic variation across 93 non-overlapping regions, with asymmetry in estimates between the left and right cerebral hemispheres. Several regions reported in previous studies to be related to Alzheimer's disease progression were estimated to have a large proportion of volumetric variance explained by the SNPs.

Phenotype

Genome-Wide Association Study

Humans

Middle Aged

Male

Alzheimer Disease - pathology

Organ Size - genetics

Aged, 80 and over

Brain - pathology

Female

Aged

Polymorphism, Single Nucleotide

Alzheimer Disease - genetics

Details

Title: Subtitle: Mapping the genetic variation of regional brain volumes as explained by all common SNPs from the ADNI study
Creators: Christopher Bryant - Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
Kelly S Giovanello
Joseph G Ibrahim
Jing Chang
Dinggang Shen
Bradley S Peterson
Hongtu Zhu
Alzheimer's Disease Neuroimaging Initiative
Contributors: Laura L Boles-Ponto (Contributor) - University of Iowa, Radiology
Resource Type: Journal article
Publication Details: PloS one, Vol.8(8), pp.e71723-e71723
DOI: 10.1371/journal.pone.0071723
PMID: 24015190
PMCID: PMC3756017
NLM abbreviation: PLoS One
ISSN: 1932-6203
eISSN: 1932-6203
Publisher: Public Library of Science; United States
Grant note: T32 CA106209 / NCI NIH HHS U24 AG021886 / NIA NIH HHS P30 AG013846 / NIA NIH HHS P30 AG010129 / NIA NIH HHS P50 AG005138 / NIA NIH HHS U01 AG024904 / NIA NIH HHS P50 AG008702 / NIA NIH HHS K01 AG030514 / NIA NIH HHS P30 AG008051 / NIA NIH HHS
Language: English
Date published: 2013
Academic Unit: Radiology; Pharmaceutical Sciences and Experimental Therapeutics
Record Identifier: 9984051582502771

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