Logo image
Marginal Modelling of Categorical Data from Crossover Experiments
Journal article   Open access

Marginal Modelling of Categorical Data from Crossover Experiments

Cecile C Balagtas, Mark P Becker and Joseph B Lang
Journal of the Royal Statistical Society: Series C (Applied Statistics), Vol.44(1), pp.63-77
1995
DOI: 10.2307/2986195
url
https://doi.org/10.2307/2986195View
Published (Version of record) Open Access

Abstract

SUMMARY Marginal models provide a useful framework for the analysis of crossover experiments when the response variable is categorical. In this paper we use the three‐treatment, three‐period crossover experiment with a binary outcome variable to demonstrate how marginal models can be used to perform a likelihood‐based analysis of multiple‐period crossover experiments. Other designs are discussed in less detail. Maximum likelihood estimation is performed using a constraint equation specification of the marginal model. Data from a crossover trial comparing treatments for primary dysmenorrhoea are used to demonstrate the utility of marginal models in analysing crossover data.
Carry‐over effects Constraint equations Lagrange multipliers Maximum likelihood Repeated measures Treatment‐by‐period interaction

Details

Metrics

Logo image