Journal article
Margins in Stage I and II Oral Cavity Squamous Cell Carcinoma: A Review From the American Head and Neck Society
JAMA otolaryngology-- head & neck surgery, Vol.149(7), pp.636-642
07/2023
DOI: 10.1001/jamaoto.2023.1201
PMID: 37289469
Abstract
Importance: The assessment and management of surgical margins in stage I and II oral cavity squamous cell carcinoma is one of the most important perioperative aspects of oncologic care, with profound implications for patient outcomes and adjuvant therapy. Understanding and critically reviewing the existing data surrounding margins in this context is necessary to rigorously care for this challenging group of patients and minimize patient morbidity and mortality.
Observations: This review discusses the data related to the definitions related to surgical margins, methods for assessment, specimen vs tumor bed margin evaluation, and re-resection of positive margins. The observations presented emphasize notable controversy within the field about margin assessment, with early data coalescing around several key aspects of management, although studies are limited by their design.
Conclusions and relevance: Stage I and II oral cavity cancer requires surgical resection with negative margins to obtain optimal oncologic outcomes, but controversy persists over margin assessment. Future studies with improved, well-controlled study designs are required to more definitively guide margin assessment and management.
Details
- Title: Subtitle
- Margins in Stage I and II Oral Cavity Squamous Cell Carcinoma: A Review From the American Head and Neck Society
- Creators
- Sidharth V Puram - Washington University in St. LouisAshley C Mays - Cleveland Clinic FloridaRodrigo Bayon - University of IowaDiana Bell - City Of Hope National Medical CenterJeffson Chung - West Virginia UniversityChristopher E Fundakowski - Thomas Jefferson UniversityBradley T Johnson - Ear, Nose, Throat and Plastic Surgery Associates, AdventHealth, Winter Park, FloridaSean T Massa - Saint Louis UniversityArun Sharma - Southern Illinois University School of MedicineMark A Varvares - Massachusetts Eye and Ear Infirmary
- Resource Type
- Journal article
- Publication Details
- JAMA otolaryngology-- head & neck surgery, Vol.149(7), pp.636-642
- DOI
- 10.1001/jamaoto.2023.1201
- PMID
- 37289469
- ISSN
- 2168-6181
- eISSN
- 2168-619X
- Language
- English
- Electronic publication date
- 06/08/2023
- Date published
- 07/2023
- Academic Unit
- Otolaryngology
- Record Identifier
- 9984433851202771
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