Marijuana alters the human cerebellar clock

Daniel S O'Leary; Robert I Block; Beth M Turner; Julie Koeppel; Vincent A Magnotta; Laura Boles Ponto; G Leonard Watkins; Richard D Hichwa; Nancy C Andreasen

doi:10.1097/00001756-200306110-00009

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Marijuana alters the human cerebellar clock

Journal article

Peer reviewed

Marijuana alters the human cerebellar clock

Daniel S O'Leary, Robert I Block, Beth M Turner, Julie Koeppel, Vincent A Magnotta, Laura Boles Ponto, G Leonard Watkins, Richard D Hichwa and Nancy C Andreasen

Neuroreport, Vol.14(8), pp.1145-1151

06/11/2003

DOI: 10.1097/00001756-200306110-00009

PMID: 12821798

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Abstract

The effects of marijuana on brain perfusion and internal timing were assessed using [15O] water PET in occasional and chronic users. Twelve volunteers who smoked marijuana recreationally about once weekly, and 12 volunteers who smoked daily for a number of years performed a self-paced counting task during PET imaging, before and after smoking marijuana and placebo cigarettes. Smoking marijuana increased rCBF in the ventral forebrain and cerebellar cortex in both groups, but resulted in significantly less frontal lobe activation in chronic users. Counting rate increased after smoking marijuana in both groups, as did a behavioral measure of self-paced tapping, and both increases correlated with rCBF in the cerebellum. Smoking marijuana appears to accelerate a cerebellar clock altering self-paced behaviors.

Brain - diagnostic imaging

Verbal Behavior

Humans

Cerebellum - drug effects

Male

Cognition

Cerebellum - physiology

Brain - physiology

Marijuana Smoking - physiopathology

Case-Control Studies

Dronabinol - blood

Cannabis - chemistry

Placebos

Adult

Female

Psychomotor Performance

Heart Rate

Marijuana Smoking - adverse effects

Cannabis - toxicity

Cerebrovascular Circulation - drug effects

Image Processing, Computer-Assisted - methods

Tomography, Emission-Computed - methods

Ego

Brain - drug effects

Neuropsychological Tests

Marijuana Smoking - blood

Regional Blood Flow - physiology

Details

Title: Subtitle: Marijuana alters the human cerebellar clock
Creators: Daniel S O'Leary - Department of Psychiatry, University of Iowa Hospital and Clinic, Iowa City, IA 52242, USA. daniel-oleary@uiowa.edu
Robert I Block
Beth M Turner
Julie Koeppel
Vincent A Magnotta
Laura Boles Ponto
G Leonard Watkins
Richard D Hichwa
Nancy C Andreasen
Resource Type: Journal article
Publication Details: Neuroreport, Vol.14(8), pp.1145-1151
Publisher: England
DOI: 10.1097/00001756-200306110-00009
PMID: 12821798
ISSN: 0959-4965
eISSN: 1473-558X
Grant note: DA10551 / NIDA NIH HHS
Language: English
Date published: 06/11/2003
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Psychiatry; Research Administration; Iowa Neuroscience Institute; Pharmaceutical Sciences and Experimental Therapeutics; Physics and Astronomy; Radiation Oncology; Anesthesia
Record Identifier: 9984003997802771

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