Journal article
Marine natural products as sources of antiviral, antimicrobial, and antineoplastic agents
Pure and applied chemistry, Vol.53(4), pp.795-817
01/01/1981
DOI: 10.1351/pac198153040795
Abstract
Extracts of marine species from Baja California and the Caribbean have been examined on shipboard for a variety of bioactl-vities and their constituents studied there by gas chromatography/ mass spectrometry. A very high proportion of the extracts has been shown to be cytotoxic, a high proportion to be antibacterial or antifungal and a surprisingly large number to be antiviral. Many of these activities have been confirmed in more extensive assays against tumor cells, pathogenic microorganisms and a battery of viruses. A number of the compounds responsible for the activities have been identified, including several new compounds. Of special current interest are the didemnins, depsipeptides isolated from a didemnid tunicate, which inhibit a number of RNA and DNA viruses and exhibit potent cytotoxicity vs_. tumor cell lines. © 1981, Walter de Gruyter. All rights reserved.
Details
- Title: Subtitle
- Marine natural products as sources of antiviral, antimicrobial, and antineoplastic agents
- Creators
- K. L RinehartP. D ShawL. S ShieldJ. B GloerG. C HarbourM. E. S KokerD SamainR. E SchwartzA. A TymiakD. L WellerG. T CarterM. H. G MunroR. G HughesH. E RenisE. B SwynenbergD. A StringfellowJ. J VavraJ. H CoatsG. E ZurenkoS. L KuentzelL. H LiG. J BakusR. C BruscaL. L CraftD. N YoungJ. L Connor
- Resource Type
- Journal article
- Publication Details
- Pure and applied chemistry, Vol.53(4), pp.795-817
- DOI
- 10.1351/pac198153040795
- ISSN
- 0033-4545
- eISSN
- 1365-3075
- Language
- English
- Date published
- 01/01/1981
- Academic Unit
- Chemistry
- Record Identifier
- 9984216560502771
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