Journal article
Markers of inflammation and coagulation after long-term exposure to coarse particulate matter: a cross-sectional analysis from the multi-ethnic study of atherosclerosis
Environmental health perspectives, Vol.123(6), pp.541-548
06/2015
DOI: 10.1289/ehp.1308069
PMCID: PMC4455582
PMID: 25616153
Abstract
Toxicological research suggests that coarse particles (PM10-2.5) are inflammatory, but responses are complex and may be best summarized by multiple inflammatory markers. Few human studies have investigated associations with PM10-2.5 and, of those, none have explored long-term exposures. Here we examine long-term associations with inflammation and coagulation in the Multi-Ethnic Study of Atherosclerosis.
Participants included 3,295 adults (45-84 years of age) from three metropolitan areas. Site-specific spatial models were used to estimate 5-year concentrations of PM10-2.5 mass and copper, zinc, phosphorus, silicon, and endotoxin found in PM10-2.5. Outcomes included interleukin-6, C-reactive protein, fibrinogen, total homocysteine, D-dimer, factor VIII, plasmin-antiplasmin complex, and inflammation and coagulation scores. We used multivariable regression with multiply imputed data to estimate associations while controlling for potential confounders, including co-pollutants such as fine particulate matter.
Some limited evidence was found of relationships between inflammation and coagulation and PM10-2.5. Endotoxin was the PM10-2.5 component most strongly associated with inflammation, with an interquartile range (IQR) increase (0.08 EU/m3) associated with 0.15 (95% CI: 0.01, 0.28; p = 0.03) and 0.08 (95% CI: -0.07, 0.23; p = 0.28) higher inflammation scores before and after control for city, respectively. Copper was the component with the strongest association with coagulation, with a 4-ng/m3 increase associated with 0.19 (95% CI: 0.08, 0.30; p = 0.0008) and 0.12 (95% CI: -0.05, 0.30; p = 0.16) unit higher coagulation scores before and after city adjustment, respectively.
Our cross-sectional analysis provided some evidence that long-term PM10-2.5 exposure was associated with inflammation and coagulation, but associations were modest and depended on particle composition.
Details
- Title: Subtitle
- Markers of inflammation and coagulation after long-term exposure to coarse particulate matter: a cross-sectional analysis from the multi-ethnic study of atherosclerosis
- Creators
- Sara D Adar - Department of Epidemiology, University of Michigan, Ann Arbor, Michigan, USAJennifer D'SouzaKari Mendelsohn-VictorDavid R JacobsMary CushmanLianne SheppardPeter S ThorneGregory L BurkeMartha L DaviglusAdam A SzpiroAna V Diez RouxJoel D KaufmanTimothy V Larson
- Resource Type
- Journal article
- Publication Details
- Environmental health perspectives, Vol.123(6), pp.541-548
- Publisher
- United States
- DOI
- 10.1289/ehp.1308069
- PMID
- 25616153
- PMCID
- PMC4455582
- ISSN
- 0091-6765
- eISSN
- 1552-9924
- Grant note
- P30 ES005605 / NIEHS NIH HHS N01HC95159 / NHLBI NIH HHS N01HC95169 / NHLBI NIH HHS K24 ES013195 / NIEHS NIH HHS N01-HC-95159 / NHLBI NIH HHS N01-HC-95169 / NHLBI NIH HHS P30-ES07033 / NIEHS NIH HHS P30 ES007033 / NIEHS NIH HHS
- Language
- English
- Date published
- 06/2015
- Academic Unit
- Civil and Environmental Engineering; Occupational and Environmental Health
- Record Identifier
- 9983997999302771
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