Journal article
‘Masked synthons’ in crystal engineering: insulated components in acetaminophen cocrystal hydrates
CrystEngComm, Vol.15(24), pp.4816-4822
2013
DOI: 10.1039/c3ce40159f
Abstract
A series of cocrystals of acetaminophen and trans-1,2-bis(4-pyridyl) ethylene are reported wherein there is a lack of direct hydrogen-bonding between the components owing to interjected water molecules. A survey of the Cambridge Structural Database demonstrates that interjected water molecules involving cocrystals with similar components are rare. We term the lack of interaction as a 'masked synthon', which we aim to contribute to the development of synthon theory in organic solid-state chemistry. © 2013 The Royal Society of Chemistry.
Details
- Title: Subtitle
- ‘Masked synthons’ in crystal engineering: insulated components in acetaminophen cocrystal hydrates
- Creators
- John R. G SanderDejan-Krešimir BučarRodger F HenryBrittany N GiangiorgiGeoff G. Z ZhangLeonard R MacGillivray
- Resource Type
- Journal article
- Publication Details
- CrystEngComm, Vol.15(24), pp.4816-4822
- DOI
- 10.1039/c3ce40159f
- ISSN
- 1466-8033
- eISSN
- 1466-8033
- Language
- English
- Date published
- 2013
- Academic Unit
- Chemistry; Pharmaceutical Sciences and Experimental Therapeutics
- Record Identifier
- 9984216676502771
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