Journal article
Mast cell degranulation breaks peripheral tolerance
American journal of transplantation, Vol.9(10), pp.2270-2280
10/2009
DOI: 10.1111/j.1600-6143.2009.02755.x
PMCID: PMC3808998
PMID: 19681828
Abstract
Mast cells (MC) have been shown to mediate regulatory T-cell (T
reg
) dependent, peripheral allograft tolerance in both skin and cardiac transplants. Furthermore, T
reg
have been implicated in mitigating IgE mediated MC degranulation, establishing a dynamic, reciprocal relationship between MC and T
reg
in controlling inflammation. In an allograft tolerance model, it is now shown that intragraft or systemic MC degranulation results in the transient loss of T
reg
suppressor activities with the acute, T-cell dependent rejection of established, tolerant allografts. Upon degranulation, MC mediators can be found in the skin, T
reg
rapidly leave the graft, MC accumulate in the regional lymph node and the T
reg
are impaired in the expression of suppressor molecules. Such a dramatic reversal of T
reg
function and tissue distribution by MC degranulation underscores how allergy may causes the transient breakdown of peripheral tolerance and episodes of acute T-cell inflammation.
Details
- Title: Subtitle
- Mast cell degranulation breaks peripheral tolerance
- Creators
- Victor C de Vries - Department of Microbiology and Immunology, Dartmouth Medical School and Norris Cotton Cancer Center, Lebanon, NH 03756Anna Wasiuk - Department of Microbiology and Immunology, Dartmouth Medical School and Norris Cotton Cancer Center, Lebanon, NH 03756Kathryn A Bennett - Department of Microbiology and Immunology, Dartmouth Medical School and Norris Cotton Cancer Center, Lebanon, NH 03756Micah J Benson - Department of Microbiology and Immunology, Dartmouth Medical School and Norris Cotton Cancer Center, Lebanon, NH 03756Raul Elgueta - Department of Microbiology and Immunology, Dartmouth Medical School and Norris Cotton Cancer Center, Lebanon, NH 03756Thomas J Waldschmidt - Department of Pathology, University of Iowa, Iowa City, IA 52242Randolph. J Noelle - Department of Microbiology and Immunology, Dartmouth Medical School and Norris Cotton Cancer Center, Lebanon, NH 03756
- Resource Type
- Journal article
- Publication Details
- American journal of transplantation, Vol.9(10), pp.2270-2280
- DOI
- 10.1111/j.1600-6143.2009.02755.x
- PMID
- 19681828
- PMCID
- PMC3808998
- NLM abbreviation
- Am J Transplant
- ISSN
- 1600-6135
- eISSN
- 1600-6143
- Grant note
- R01 AI048667-09 || AI / National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID
- Language
- English
- Date published
- 10/2009
- Academic Unit
- Pathology
- Record Identifier
- 9984046806402771
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