Maternal Alcohol Consumption, Alcohol Metabolism Genes, and the Risk of Oral Clefts: A Population-based Case-Control Study in Norway, 1996―2001

Abee L BOYLES; Lisa A DEROO; Rolv T LIE; Jack A TAYLOR; Astanand JUGESSUR; Jeffrey C MURRAY; Allen J WILCOX

doi:10.1093/aje/kwq226

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Maternal Alcohol Consumption, Alcohol Metabolism Genes, and the Risk of Oral Clefts: A Population-based Case-Control Study in Norway, 1996―2001

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Maternal Alcohol Consumption, Alcohol Metabolism Genes, and the Risk of Oral Clefts: A Population-based Case-Control Study in Norway, 1996―2001

Abee L BOYLES, Lisa A DEROO, Rolv T LIE, Jack A TAYLOR, Astanand JUGESSUR, Jeffrey C MURRAY and Allen J WILCOX

American journal of epidemiology, Vol.172(8), pp.924-931

2010

DOI: 10.1093/aje/kwq226

PMCID: PMC2984244

PMID: 20810466

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Abstract

Heavy maternal alcohol consumption during early pregnancy increases the risk of oral clefts, but little is known about how genetic variation in alcohol metabolism affects this association. Variants in the alcohol dehydrogenase 1C (ADH1C) gene may modify the association between alcohol and clefts. In a population-based case-control study carried out in Norway (1996-2001), the authors examined the association between maternal alcohol consumption and risk of oral clefts according to mother and infant ADH1C haplotypes encoding fast or slow alcohol-metabolizing phenotypes. Subjects were 483 infants with oral cleft malformations and 503 control infants and their mothers, randomly selected from all other livebirths taking place during the same period. Mothers who consumed 5 or more alcoholic drinks per sitting during the first trimester of pregnancy had an elevated risk of oral cleft in their offspring (odds ratio (OR) = 2.6, 95% confidence interval (CI): 1.4, 4.7). This increased risk was evident only in mothers or children who carried the ADH1C haplotype associated with reduced alcohol metabolism (OR= 3.0, 95% CI: 1.4, 6.8). There was no evidence of alcohol-related risk when both mother and infant carried only the rapid-metabolism ADH1C variant (OR = 0.9, 95% CI: 0.2, 4.1). The teratogenic effect of alcohol may depend on the genetic capacity of the mother and fetus to metabolize alcohol.

Epidemiology

Public health. Hygiene-occupational medicine

Public health. Hygiene

General aspects

Miscellaneous

Otorhinolaryngology. Stomatology

Non tumoral diseases

Biological and medical sciences

Medical sciences

Facial bones, jaws, teeth, parodontium: diseases, semeiology

Details

Title: Subtitle: Maternal Alcohol Consumption, Alcohol Metabolism Genes, and the Risk of Oral Clefts: A Population-based Case-Control Study in Norway, 1996―2001
Creators: Abee L BOYLES - Epidemiology Branch, National Institute of Environmental Health Sciences, Durham, North Carolina, United States
Lisa A DEROO - Epidemiology Branch, National Institute of Environmental Health Sciences, Durham, North Carolina, United States
Rolv T LIE - Section for Epidemiology and Medical Statistics, Department of Public Health and Primary Health Care, Faculty of Medicine and Dentistry, University of Bergen, Bergen, Norway
Jack A TAYLOR - Epidemiology Branch, National Institute of Environmental Health Sciences, Durham, North Carolina, United States
Astanand JUGESSUR - Division of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway
Jeffrey C MURRAY - Departments of Pediatrics, Epidemiology, and Biological Sciences, College of Public Health, University of Iowa, Iowa City, Iowa, United States
Allen J WILCOX - Epidemiology Branch, National Institute of Environmental Health Sciences, Durham, North Carolina, United States
Resource Type: Journal article
Publication Details: American journal of epidemiology, Vol.172(8), pp.924-931
DOI: 10.1093/aje/kwq226
PMID: 20810466
PMCID: PMC2984244
NLM abbreviation: Am J Epidemiol
ISSN: 0002-9262
eISSN: 1476-6256
Publisher: Oxford University Press; Cary, NC
Language: English
Date published: 2010
Academic Unit: Anatomy and Cell Biology; Stead Family Department of Pediatrics; Epidemiology; Pediatric Dentistry; Craniofacial Anomalies Research Center; Dental Research
Record Identifier: 9984025306802771

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