Maternal Body Mass Index and Lifestyle Exposures and the Risk of Bilateral Renal Agenesis or Hypoplasia

Jennifer E Slickers; Andrew F Olshan; Anna Maria Siega-Riz; Margaret A Honein; Arthur S Aylsworth; National Birth Defects Prevention Study

doi:10.1093/aje/kwn248

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Maternal Body Mass Index and Lifestyle Exposures and the Risk of Bilateral Renal Agenesis or Hypoplasia

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Maternal Body Mass Index and Lifestyle Exposures and the Risk of Bilateral Renal Agenesis or Hypoplasia

Jennifer E Slickers, Andrew F Olshan, Anna Maria Siega-Riz, Margaret A Honein, Arthur S Aylsworth and National Birth Defects Prevention Study

American journal of epidemiology, Vol.168(11), pp.1259-1267

10/03/2008

DOI: 10.1093/aje/kwn248

PMID: 18835865

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Abstract

Increased maternal body mass index, maternal smoking, and alcohol exposure during pregnancy have been inconsistently reported as potential risk factors for renal birth defects. The low incidence of the most severe renal anomaly, bilateral renal agenesis or hypoplasia (RA/H), has limited the ability to study this fatal defect. Using data from the National Birth Defects Prevention Study, a multicenter case-control study, the authors explored potential relations between RA/H and maternal body mass index, smoking, alcohol, and caffeine exposures. Data available for 75 infants with RA/H born between 1997 and 2003 and for randomly selected control infants without known birth defects (n = 868) were assessed by a model adjusted for folic acid use, all four exposures of interest, and study center. Bilateral RA/H was associated with a body mass index of greater than 30 kg/m2 prior to pregnancy (adjusted odds ratio (aOR) = 1.92, 95% confidence interval (CI): 1.00, 3.67), smoking during the periconceptional period (aOR = 2.09, 95% CI: 1.08, 4.03), and binge drinking during the second month of pregnancy (aOR = 3.64, 95% CI: 1.19, 11.1). These results support the need for further exploration into the potential mechanisms by which such exposures could interfere with early fetal kidney formation resulting in RA/H.

Caffeine

Pregnancy

alcohol drinking

body mass index

case-control studies

congenital abnormalities

kidney

smoking

Details

Title: Subtitle: Maternal Body Mass Index and Lifestyle Exposures and the Risk of Bilateral Renal Agenesis or Hypoplasia
Creators: Jennifer E Slickers
Andrew F Olshan - Correspondence to Dr. Andrew F. Olshan, Department of Epidemiology, Campus Box 7435, School of Public Health, University of North Carolina, Chapel Hill, NC 27599-7435 (e-mail: andy_olshan@unc.edu)
Anna Maria Siega-Riz
Margaret A Honein
Arthur S Aylsworth
National Birth Defects Prevention Study
Contributors: Paul A Romitti (Contributor) - University of Iowa, Epidemiology
Resource Type: Journal article
Publication Details: American journal of epidemiology, Vol.168(11), pp.1259-1267
DOI: 10.1093/aje/kwn248
PMID: 18835865
NLM abbreviation: Am J Epidemiol
ISSN: 0002-9262
eISSN: 1476-6256
Publisher: Oxford University Press
Language: English
Date published: 10/03/2008
Academic Unit: Epidemiology; Biostatistics
Record Identifier: 9984214854302771

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