Journal article
Maternal Contributions to Preterm Delivery
American journal of epidemiology, Vol.170(11), pp.1358-1364
2009
DOI: 10.1093/aje/kwp324
PMCID: PMC2800264
PMID: 19854807
Abstract
Preterm delivery (PTD) is a complex trait with a significant familial component. However, no specific inheritance patterns have been established. The authors examined the contribution of PTDs in both the woman's family and her partner's family to her risk of PTD. The authors linked birth information from Danish national registers with pedigree information from the Danish Family Relations Database for 1,107,124 live singleton deliveries occurring from 1978 to 2004. Risk ratios were estimated comparing women with and without various PTD histories. Women with previous PTDs were at greatly increased risk of recurrent PTD (risk ratio = 5.6, 95% confidence interval: 5.5, 5.8); however, their PTD risk was unaffected by a partner's history of preterm children with other women. PTDs to a woman's mother, full sisters, or maternal half-sisters also increased her PTD risk (risk ratio = 1.6, 95% confidence interval: 1.5, 1.6), whereas PTDs in her paternal half-sisters, the female partners of her male relatives, or members of her partner's family did not affect her PTD risk. Inheritance patterns were similar for all gestational ages from very early through late PTD. The substantial portion of PTD risk explained by effects passed through the female line suggests a role for either imprinting or mitochondrial inheritance.
Details
- Title: Subtitle
- Maternal Contributions to Preterm Delivery
- Creators
- Heather A BOYD - Department of Epidemiology Research, Statens Serum Institut, Copenhagen, DenmarkGry POULSEN - Department of Epidemiology Research, Statens Serum Institut, Copenhagen, DenmarkJan WOHLFAHRT - Department of Epidemiology Research, Statens Serum Institut, Copenhagen, DenmarkJeffrey C MURRAY - Department of Pediatrics, University of Iowa, Iowa City, Iowa, United StatesBjarke FEENSTRA - Department of Epidemiology Research, Statens Serum Institut, Copenhagen, DenmarkMads MELBYE - Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark
- Resource Type
- Journal article
- Publication Details
- American journal of epidemiology, Vol.170(11), pp.1358-1364
- DOI
- 10.1093/aje/kwp324
- PMID
- 19854807
- PMCID
- PMC2800264
- NLM abbreviation
- Am J Epidemiol
- ISSN
- 0002-9262
- eISSN
- 1476-6256
- Publisher
- Oxford University Press; Cary, NC
- Language
- English
- Date published
- 2009
- Academic Unit
- Anatomy and Cell Biology; Stead Family Department of Pediatrics; Epidemiology; Pediatric Dentistry; Craniofacial Anomalies Research Center; Dental Research
- Record Identifier
- 9984025304902771
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