Journal article
Maternal Dietary Patterns are Associated With Risk of Neural Tube and Congenital Heart Defects
American journal of epidemiology, Vol.177(11), pp.1279-1288
2013
DOI: 10.1093/aje/kws349
PMCID: PMC3664332
PMID: 23639938
Abstract
Studying empirically derived dietary patterns is useful in understanding dietary practice. We classified women by their dietary patterns using latent class analysis of 66 foods and studied the association of these patterns with neural tube defects (NTDs) and congenital heart defects (CHDs) in the US National Birth Defects Prevention Study (1997–2005). Logistic regression models used data from 1,047 with an NTD, 6,641 with a CHD, and 6,123 controls that were adjusted for maternal characteristics and tested the effect modification of multivitamin supplement use. Four latent dietary patterns were identified: prudent, Western, low-calorie Western, and Mexican. Among participants who did not use supplements, those in the Mexican, Western, and low-calorie Western classes were significantly more likely (odds ratios of 1.6, 1.5, and 1.4, respectively) to have offspring born with NTDs than were those in the prudent class after adjustment of for dietary folic acid intake. In contrast, among supplement users, there was no difference in the incidence of NTDs between classes. Associations between dietary class and CHD subgroups were not modified by supplement use except for tetralogy of Fallot; among supplement users, those in the Western class were twice as likely (95% confidence interval: 1.4, 2.8) as the prudent class to have offspring with tetralogy of Fallot. Women who adhered to a Western diet were 1.2 (95% confidence interval: 1.03, 1.35) times more likely to have an infant with septal heart defect than were women who adhered to a prudent diet. A prudent dietary pattern, even with folate fortification, may decrease the risk of NTDs and some heart defects.
Details
- Title: Subtitle
- Maternal Dietary Patterns are Associated With Risk of Neural Tube and Congenital Heart Defects
- Creators
- Daniela SOTRES-ALVAREZ - Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United StatesAnna Maria SIEGA-RIZ - Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United StatesAmy H Herring - Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United StatesSuzan L Carmichael - Neonatal and Developmental Medicine, Department of Pediatrics, School of Medicine, Stanford University, Palo Alto, California, United StatesMarcia L Feldkamp - Division of Medical Genetics, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah, United StatesCharlotte A Hobbs - Department of Pediatrics, Birth Defects Research Section, University of Arkansas for Medical Sciences and Arkansas Children's Hospital Research Institute, Little Rock, Arkansas, United StatesAndrew F Olshan - Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United StatesNational Birth Defects Prevention Study
- Contributors
- Paul A Romitti (Contributor) - University of Iowa, Epidemiology
- Resource Type
- Journal article
- Publication Details
- American journal of epidemiology, Vol.177(11), pp.1279-1288
- Publisher
- Oxford University Press
- DOI
- 10.1093/aje/kws349
- PMID
- 23639938
- PMCID
- PMC3664332
- ISSN
- 0002-9262
- eISSN
- 1476-6256
- Language
- English
- Date published
- 2013
- Academic Unit
- Epidemiology; Biostatistics
- Record Identifier
- 9984213372202771
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