Journal article
Maternal Exposure to Tap Water Disinfection By-Products and Risk of Selected Congenital Heart Defects
Birth defects research, Vol.116(9), e2391
09/2024
DOI: 10.1002/bdr2.2391
PMCID: PMC11440226
PMID: 39212068
Abstract
ABSTRACT Background The use of chlorine to treat drinking water produces disinfection byâ€products (DBPs), which have been associated with congenital heart defects (CHDs) in some studies. Methods Using National Birth Defects Prevention Study data, we linked geocoded residential addresses to public water supply measurement data for DBPs. Selfâ€reported water consumption and filtration methods were used to estimate maternal ingestion of DBPs. We estimated adjusted odds ratios and 95% confidence intervals using logistic regression controlling for maternal age, education, body mass index (BMI), race/ethnicity, and study site to examine associations between CHDs and both household DBP level and estimated ingestion of DBPs. Results Household DBP exposure was assessed for 2717 participants (1495 cases and 1222 controls). We observed a broad range of positive, null, and negative estimates across eight specific CHDs and two summary exposures (trihalomethanes and haloacetic acids) plus nine individual DBP species. Examining ingestion exposure among 2488 participants (1347 cases, 1141 controls) produced similarly inconsistent results. Conclusions Assessing both household DBP level and estimated ingestion of DBPs, we did not find strong evidence of an association between CHDs and DBPs. Despite a large study population, DBP measurements were available for less than half of participant addresses, limiting study power.
Details
- Title: Subtitle
- Maternal Exposure to Tap Water Disinfection By-Products and Risk of Selected Congenital Heart Defects
- Creators
- Adrian M. Michalski - New York State Department of HealthThomas J. Luben - University of North Carolina at Chapel HillIbrahim Zaganjor - University of North Carolina at Chapel HillAnthony Rhoads - University of IowaPaul A. Romitti - Department of Epidemiology, College of Public Health The University of Iowa Iowa City Iowa USAKristin M. Conway - University of Iowa, EpidemiologyPeter H. Langlois - University of Texas Health Science Center at DallasMarcia L. Feldkamp - University of UtahWendy N. Nembhard - University of Arkansas for Medical SciencesJennita Reefhuis - Centers for Disease Control and PreventionMahsa M. Yazdy - Massachusetts Department of Public HealthAngela E. Lin - Massachusetts General HospitalTania A. Desrosiers - University of North Carolina at Chapel HillAdrienne T. Hoyt - University of HoustonMarilyn L. Browne - University at Albany, State University of New YorkNational Birth Defects Prevention Study
- Resource Type
- Journal article
- Publication Details
- Birth defects research, Vol.116(9), e2391
- DOI
- 10.1002/bdr2.2391
- PMID
- 39212068
- PMCID
- PMC11440226
- NLM abbreviation
- Birth Defects Res
- ISSN
- 2472-1727
- eISSN
- 2472-1727
- Publisher
- Wiley
- Grant note
- Centers for Disease Control and Prevention (CDC): 96043, 02081, DD09-001, DD13-003, DD18-001
This project was supported through Centers for Disease Control and Prevention (CDC) cooperative agreements under PA #96043, PA #02081, FOA #DD09-001, FOA #DD13-003, and NOFO #DD18-001 to the Centers for Birth Defects Research and Prevention participating in the National Birth Defects Prevention Study (NBDPS) and/or the Birth Defects Study To Evaluate Pregnancy exposures (BD-STEPS).
- Language
- English
- Date published
- 09/2024
- Academic Unit
- Epidemiology; Biostatistics
- Record Identifier
- 9984701754902771
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