Journal article
Maternal-Fetal Transfer and Toxicokinetics of 2,2',5,5'-Tetrachlorobiphenyl, [ 14 C]-PCB52, Following Intratracheal Administration
Chemical research in toxicology, Vol.38(11), pp.1944-1960
11/03/2025
DOI: 10.1021/acs.chemrestox.5c00265
PMCID: PMC12794188
PMID: 41182394
Appears in UI Libraries Support Open Access
Abstract
Despite increased recognition of the adverse impacts of PCB exposure on human health, comprehensive risk assessments, particularly regarding inhalation exposure and effects on the developing fetus, are lacking. Out of all PCB congeners, lower-chlorinated PCBs have been more prevalent in indoor and outdoor atmospheres. Thus, we investigated
toxicokinetics and placental transfer of radiolabeled [
C]-PCB52 (0.157 mg/kg administered intratracheally) in Sprague-Dawley rats at gestational day 11 ± 1. Following dosing, 99.4 ± 0.5% of the administered dose was distributed to the systemic circulation. Radioactivity disappeared biexponentially following lung exposure, with 41.1% of the dose retained after 96 h. PCB52 was rapidly distributed to the maternal serum, lung, heart, and liver, with subsequent accumulation in the ovaries, brain, white and brown adipose, muscle, and mammary glands. The time to reach a maximum concentration in the maternal serum was 0.21 h, with an apparent terminal elimination half-life of 40.7 h. The peak concentration of [
C]-PCB52 and its metabolites in the placenta, fetus, and amniotic fluid was achieved 1.7 h after exposure, with a fetal half-life of 34.8 h. The maternal serum level was significantly correlated with levels in amniotic fluid, placenta, fetus, and the maternal brain. However, PCB52 exposure in the placenta, fetus, and amniotic fluid was limited with their respective maternal serum exposure ratio values of 0.5, 0.27, and 0.05. These results demonstrate for the first time a comprehensive whole-body disposition of PCB52 in dams and fetuses after lung exposure during gestation. PCB52 and its metabolites accumulate predominantly in the ovaries, brain, and mammary glands. The apparent half-life of PCB52 in developing fetuses and placenta is comparable to that of maternal serum. This study provides novel quantitative foundations for the development and evaluation of physiologically based toxicokinetic modeling to inform the exposure and risk assessment for public health decisions.
Details
- Title: Subtitle
- Maternal-Fetal Transfer and Toxicokinetics of 2,2',5,5'-Tetrachlorobiphenyl, [ 14 C]-PCB52, Following Intratracheal Administration
- Creators
- Yau Adamu - University of IowaAndrea Adamcakova-Dodd - University of IowaXuefang Jing - University of IowaDustin MayPeter S Thorne - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Chemical research in toxicology, Vol.38(11), pp.1944-1960
- DOI
- 10.1021/acs.chemrestox.5c00265
- PMID
- 41182394
- PMCID
- PMC12794188
- NLM abbreviation
- Chem Res Toxicol
- ISSN
- 0893-228X
- eISSN
- 1520-5010
- Publisher
- American Chemical Society
- Grant note
- National Institute of Environmental Health Sciences: P30ES005605
The authors thank Drs. Guohua An, Hans-Joachim Lehmler, Andres Martinez, and Kai Wang of the University of Iowa for their valuable comments and guidance on Dr. Adamu's dissertation research, of which this study forms a part. The authors sincerely thank Dr. Dong Keun Lee for helping with intratracheal dosing during animal exposure and the Iowa Inflammation Program and the Iowa State Hygienic Laboratory for allowing us to use their liquid scintillation counters. The authors also thank Dr. An for providing access to the Phoenix PK Software and Dr. Lehmler and the Analytical Core of the Iowa Superfund Research Program for providing unlabeled-PCB standards used in this study.
- Language
- English
- Date published
- 11/03/2025
- Academic Unit
- Civil and Environmental Engineering; Occupational and Environmental Health
- Record Identifier
- 9985024145802771
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