Journal article
Maternal Gestational Hypertension-Induced Sensitization of Angiotensin II Hypertension Is Reversed by Renal Denervation or Angiotensin-Converting Enzyme Inhibition in Rat Offspring
Hypertension (Dallas, Tex. 1979), Vol.69(4), pp.669-677
04/2017
DOI: 10.1161/HYPERTENSIONAHA.116.08597
PMCID: PMC5344733
PMID: 28223469
Abstract
Numerous findings demonstrate that there is a strong association between maternal health during pregnancy and cardiovascular disease in adult offspring. The purpose of the present study was to test whether maternal gestational hypertension modulates brain renin-angiotensin-aldosterone system (RAAS) and proinflammatory cytokines that sensitizes angiotensin II-elicited hypertensive response in adult offspring. In addition, the role of renal nerves and the RAAS in the sensitization process was investigated. Reverse transcription polymerase chain reaction analyses of structures of the lamina terminalis and paraventricular nucleus indicated upregulation of mRNA expression of several RAAS components and proinflammatory cytokines in 10-week-old male offspring of hypertensive dams. Most of these increases were significantly inhibited by either renal denervation performed at 8 weeks of age or treatment with an angiotensin-converting enzyme inhibitor, captopril, in drinking water starting at weaning. When tested beginning at 10 weeks of age, a pressor dose of angiotensin II resulted in enhanced upregulation of mRNA expression of RAAS components and proinflammatory cytokines in the lamina terminalis and paraventricular nucleus and an augmented pressor response in male offspring of hypertensive dams. The augmented blood pressure change and most of the increases in gene expression in the offspring were abolished by either renal denervation or captopril. The results suggest that maternal hypertension during pregnancy enhances pressor responses to angiotensin II through overactivity of renal nerves and the RAAS in male offspring and that upregulation of the brain RAAS and proinflammatory cytokines in these offspring may contribute to maternal gestational hypertension-induced sensitization of the hypertensive response to angiotensin II.
Details
- Title: Subtitle
- Maternal Gestational Hypertension-Induced Sensitization of Angiotensin II Hypertension Is Reversed by Renal Denervation or Angiotensin-Converting Enzyme Inhibition in Rat Offspring
- Creators
- Baojian Xue - From the Departments of Psychological and Brain Sciences (B.X., F.G., T.G.B., R.L.T., A.K.J.), Pharmacology (A.K.J.), and the Francois M. Abboud Cardiovascular Research Center (B.X., A.K.J.), University of Iowa, Iowa City; and Department of Biology, Hebei North University, China (H.Y.). baojian-xue@uiowa.edu alan-johnson@uiowa.eduHaifeng Yin - From the Departments of Psychological and Brain Sciences (B.X., F.G., T.G.B., R.L.T., A.K.J.), Pharmacology (A.K.J.), and the Francois M. Abboud Cardiovascular Research Center (B.X., A.K.J.), University of Iowa, Iowa City; and Department of Biology, Hebei North University, China (H.Y.)Fang Guo - From the Departments of Psychological and Brain Sciences (B.X., F.G., T.G.B., R.L.T., A.K.J.), Pharmacology (A.K.J.), and the Francois M. Abboud Cardiovascular Research Center (B.X., A.K.J.), University of Iowa, Iowa City; and Department of Biology, Hebei North University, China (H.Y.)Terry G Beltz - From the Departments of Psychological and Brain Sciences (B.X., F.G., T.G.B., R.L.T., A.K.J.), Pharmacology (A.K.J.), and the Francois M. Abboud Cardiovascular Research Center (B.X., A.K.J.), University of Iowa, Iowa City; and Department of Biology, Hebei North University, China (H.Y.)Robert L Thunhorst - From the Departments of Psychological and Brain Sciences (B.X., F.G., T.G.B., R.L.T., A.K.J.), Pharmacology (A.K.J.), and the Francois M. Abboud Cardiovascular Research Center (B.X., A.K.J.), University of Iowa, Iowa City; and Department of Biology, Hebei North University, China (H.Y.)Alan Kim Johnson - From the Departments of Psychological and Brain Sciences (B.X., F.G., T.G.B., R.L.T., A.K.J.), Pharmacology (A.K.J.), and the Francois M. Abboud Cardiovascular Research Center (B.X., A.K.J.), University of Iowa, Iowa City; and Department of Biology, Hebei North University, China (H.Y.). baojian-xue@uiowa.edu alan-johnson@uiowa.edu
- Resource Type
- Journal article
- Publication Details
- Hypertension (Dallas, Tex. 1979), Vol.69(4), pp.669-677
- DOI
- 10.1161/HYPERTENSIONAHA.116.08597
- PMID
- 28223469
- PMCID
- PMC5344733
- ISSN
- 0194-911X
- eISSN
- 1524-4563
- Grant note
- P01 HL014388 / NHLBI NIH HHS R01 HL098207 / NHLBI NIH HHS
- Language
- English
- Date published
- 04/2017
- Academic Unit
- Psychological and Brain Sciences; Neuroscience and Pharmacology; Neurology (Pediatrics); Health and Human Physiology
- Record Identifier
- 9984213417302771
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