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Maternal High-Fat Diet Programs for Metabolic Disturbances in Offspring despite Leptin Sensitivity
Journal article   Open access   Peer reviewed

Maternal High-Fat Diet Programs for Metabolic Disturbances in Offspring despite Leptin Sensitivity

Ana Maria Volpato, Alini Schultz, Eduardo Magalhães-da-Costa, Marcelo Lima de Gusmão Correia, Márcia Barbosa Águila and Carlos Alberto Mandarim-de-Lacerda
Neuroendocrinology, Vol.96(4), pp.272-284
12/2012
DOI: 10.1159/000336377
PMID: 22456428
url
https://doi.org/10.1159/000336377View
Published (Version of record) Open Access

Abstract

A fatty diet during pregnancy in mouse dams causes metabolic abnormalities (similar to metabolic syndrome in humans) in the rodents’ offspring. We tested the hypothesis that the offspring of dams fed a high-fat diet during pregnancy and lactation develop metabolic abnormalities and leptin resistance. Pregnant C57BL/6 mice (n = 20) were fed either standard chow (SC; 19% fat) or a high-fat diet (HF; 49% fat). After weaning, male offspring were divided into four groups, according to the diet of dams and offspring: SC(dams)/SC(offspring), SC/HF, HF/SC and HF/HF (n = 30/group). For a metabolic analysis, we evaluated body mass, fat mass depots, blood plasma and adipocyte structure at 12 weeks of age. To analyse leptin sensitivity, each group was divided into two groups (vehicle or leptin) to identify the feeding response and pSTAT3 expression after acute intracerebroventricular (ICV) treatment. The offspring of mothers fed a high-fat diet presented increased body mass and visceral fat, adipocyte hypertrophy and insulin resistance. This phenotype was not associated with central leptin resistance. Thus, maternal programming by HF predisposes offspring to metabolic abnormalities despite leptin sensitivity.
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