Journal article
Maternal Inflammation and Neurodevelopmental Programming: A Review of Preclinical Outcomes and Implications for Translational Psychiatry
Biological psychiatry (1969), Vol.85(2), pp.107-121
01/15/2019
DOI: 10.1016/j.biopsych.2018.08.008
PMID: 30318336
Abstract
Early disruptions to neurodevelopment are highly relevant to understanding both psychiatric risk and underlying pathophysiology that can be targeted by new treatments. Much convergent evidence from the human literature associates inflammation during pregnancy with later neuropsychiatric disorders in offspring. Preclinical models of prenatal inflammation have been developed to examine the causal maternal physiological and offspring neural mechanisms underlying these findings. Here we review the strengths and limitations of preclinical models used for these purposes and describe selected studies that have shown maternal immune impacts on the brain and behavior of offspring. Maternal immune activation in mice, rats, nonhuman primates, and other mammalian model species have demonstrated convergent outcomes across methodologies. These outcomes include shifts and/or disruptions in the normal developmental trajectory of molecular and cellular processes in the offspring brain. Prenatal developmental origins are critical to a mechanistic understanding of maternal immune activation–induced alterations to microglia and immune molecules, brain growth and development, synaptic morphology and physiology, and anxiety- and depression-like, sensorimotor, and social behaviors. These phenotypes are relevant to brain functioning across domains and to anxiety and mood disorders, schizophrenia, and autism spectrum disorder, in which they have been identified. By turning a neurodevelopmental lens on this body of work, we emphasize the importance of acute changes to the prenatal offspring brain in fostering a better understanding of potential mechanisms for intervention. Collectively, overlapping results across maternal immune activation studies also highlight the need to examine preclinical offspring neurodevelopment alterations in terms of a multifactorial immune milieu, or immunome, to determine potential mechanisms of psychiatric risk.
Details
- Title: Subtitle
- Maternal Inflammation and Neurodevelopmental Programming: A Review of Preclinical Outcomes and Implications for Translational Psychiatry
- Creators
- Serena B Gumusoglu - Interdisciplinary Graduate Program in Neuroscience, University of Iowa, Iowa City, IowaHanna E Stevens - Interdisciplinary Graduate Program in Neuroscience, University of Iowa, Iowa City, Iowa
- Resource Type
- Journal article
- Publication Details
- Biological psychiatry (1969), Vol.85(2), pp.107-121
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.biopsych.2018.08.008
- PMID
- 30318336
- ISSN
- 0006-3223
- eISSN
- 1873-2402
- Grant note
- DOI: 10.13039/100001024, name: Roy J. Carver Charitable Trust; DOI: 10.13039/100012011, name: Graduate College, University of Iowa
- Language
- English
- Date published
- 01/15/2019
- Academic Unit
- Psychiatry; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Obstetrics and Gynecology
- Record Identifier
- 9984003982302771
Metrics
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