Journal article
Maternal Microvascular Dysfunction During and After Preeclamptic Pregnancy
Comprehensive Physiology, Vol.14(4), pp.5703-5727
10/09/2024
DOI: 10.1002/cphy.c240003
PMCID: PMC12974215
PMID: 39382165
Abstract
Preeclampsia, a pregnancy disorder characterized by de novo hypertension and maternal multisystem organ dysfunction, is the leading cause of maternal mortality worldwide and is associated with a fourfold greater risk of cardiovascular disease throughout the lifespan. Current understanding of the etiology of preeclampsia remains unclear, due in part to the varying phenotypical presentations of the disease, which has hindered the development of effective and mechanism-specific treatment or prevention strategies both during and after the affected pregnancy. These maternal sequelae of preeclampsia are symptoms of systemic vascular dysfunction in the maternal nonreproductive microvascular beds that drives the development and progression of adverse cardiovascular outcomes during preeclampsia. Despite normalization of vascular disturbances after delivery, subclinical dysfunction persists in the nonreproductive microvascular beds, contributing to an increased lifetime risk of cardiovascular and metabolic diseases and all-cause mortality. Given that women with a history of preeclampsia demonstrate vascular dysfunction despite an absence of traditional CVD risk factors, an understanding of the underlying mechanisms of microvascular dysfunction during and after preeclampsia is essential to identify potential therapeutic avenues to mitigate or reverse the development of overt disease. This article aims to provide a summary of the existing literature on the pathophysiology of maternal microvascular dysfunction during preeclampsia, the mechanisms underlying the residual dysfunction that remains after delivery, and current and potential treatments both during and after the affected pregnancy that may reduce microvascular dysfunction in these high-risk women. © 2024 American Physiological Society. Compr Physiol 14:5703-5727, 2024.
Details
- Title: Subtitle
- Maternal Microvascular Dysfunction During and After Preeclamptic Pregnancy
- Creators
- Kelsey S Schwartz - University of IowaAnna E Stanhewicz - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Comprehensive Physiology, Vol.14(4), pp.5703-5727
- DOI
- 10.1002/cphy.c240003
- PMID
- 39382165
- PMCID
- PMC12974215
- NLM abbreviation
- Compr Physiol
- eISBN
- 9780470650714; 0470650710
- ISSN
- 2040-4603
- eISSN
- 2040-4603
- Publisher
- WILEY
- Grant note
- American Heart Association: CDA937990 National Institutes of Health: R01HL169201
Acknowledgements This work was supported by the American Heart Association under grant number CDA937990 (A.E.S.) and the National Institutes of Health under grant number R01HL169201 (A.E.S.) .
- Language
- English
- Date published
- 10/09/2024
- Academic Unit
- Fraternal Order of Eagles Diabetes Research Center; Health, Sport, and Human Physiology ; Internal Medicine
- Record Identifier
- 9984734286802771
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