Journal article
Maternal Myo-Inositol Intake and Congenital Heart Defects in Offspring: A Population-Based Case-Control Study
BJOG : an international journal of obstetrics and gynaecology, Vol.133(3), pp.442-453
02/2026
DOI: 10.1111/1471-0528.70045
PMCID: PMC12770076
PMID: 41307476
Abstract
To investigate associations between maternal periconceptional (three months prior through the third pregnancy month) myo-inositol intake and the odds of selected congenital heart defects in offspring.
A population-based case-control study using the National Birth Defects Prevention Study (NBDPS) database.
United States.
Women with singleton live births without major birth defects (controls) and women with singleton live births, stillbirths, or terminations with selected nonsyndromic congenital heart defects (CHD; cases).
Descriptive analyses, logistic regression models, ascertainment of myo-inositol intake from supplements and food using a shortened food frequency questionnaire and survey.
Odds of CHD.
11 752 cases and 11 415 controls were included. Compared to women not taking myo-inositol supplements, women with any supplemental intake were less likely to have a pregnancy with the selected congenital heart defects as a group (adjusted odds ratio [aOR] = 0.79; 95% confidence interval [CI] 0.66-0.94) or with septal defects alone (aOR = 0.61; 95% CI 0.46-0.81). Compared to women with low total myo-inositol intake from food or supplements, women with high total myo-inositol intake (≥ 500 mg/day) were less likely to have a pregnancy with the selected CHD as a group (aOR = 0.88; 95% CI 0.84-0.93) or conotruncal defects (aOR = 0.87; 95% CI 0.79-0.96); left ventricular outflow tract defects (aOR = 0.87; 95% CI 0.78-0.96); right ventricular outflow tract defects (aOR = 0.85; 95% CI 0.77-0.95); or atrial septal defects (aOR = 0.91; 95% CI 0.83-0.99).
An inverse association was observed between maternal myo-inositol intake during the periconceptional period and the odds of selected CHDs in offspring.
Details
- Title: Subtitle
- Maternal Myo-Inositol Intake and Congenital Heart Defects in Offspring: A Population-Based Case-Control Study
- Creators
- Ruiqi Cen - University of Arkansas for Medical SciencesL Joseph Su - The University of Texas Southwestern Medical CenterJun Ying - University of Colorado Anschutz Medical CampusMohammed S Orloff - University of Arkansas for Medical SciencesElijah H Bolin - Arkansas Children's HospitalXiangyang Lou - University of Florida Health Science CenterLynn M Almli - National Center on Birth Defects and Developmental DisabilitiesLorenzo D Botto - University of UtahMarilyn L Browne - University at Albany, State University of New YorkRichard H Finnell - Baylor College of MedicineMary M Jenkins - National Center on Birth Defects and Developmental DisabilitiesEirini Nestoridi - Massachusetts Department of Public HealthAndrew F Olshan - University of North Carolina at Chapel HillPaul A Romitti - University of IowaGary M Shaw - Stanford UniversityWendy N Nembhard - University of Arkansas for Medical SciencesNational Birth Defects Prevention Study
- Resource Type
- Journal article
- Publication Details
- BJOG : an international journal of obstetrics and gynaecology, Vol.133(3), pp.442-453
- DOI
- 10.1111/1471-0528.70045
- PMID
- 41307476
- PMCID
- PMC12770076
- NLM abbreviation
- BJOG
- ISSN
- 1471-0528
- eISSN
- 1471-0528
- Publisher
- Wiley
- Grant note
- CDC HHS University of North Carolina Clinical Nutrition Research Center
- Language
- English
- Electronic publication date
- 11/27/2025
- Date published
- 02/2026
- Academic Unit
- Epidemiology; Biostatistics
- Record Identifier
- 9985034938902771
Metrics
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