Maternal Nicotinamide Riboside Enhances Postpartum Weight Loss, Juvenile Offspring Development, and Neurogenesis of Adult Offspring

Po Hien Ear; Ankita Chadda; Serena B Gumusoglu; Mark S Schmidt; Sophia Vogeler; Johnny Malicoat; Jacob Kadel; Michelle M Moore; Marie E Migaud; Hanna E Stevens; Charles Brenner

doi:10.1016/j.celrep.2019.01.007

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Maternal Nicotinamide Riboside Enhances Postpartum Weight Loss, Juvenile Offspring Development, and Neurogenesis of Adult Offspring

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Maternal Nicotinamide Riboside Enhances Postpartum Weight Loss, Juvenile Offspring Development, and Neurogenesis of Adult Offspring

Po Hien Ear, Ankita Chadda, Serena B Gumusoglu, Mark S Schmidt, Sophia Vogeler, Johnny Malicoat, Jacob Kadel, Michelle M Moore, Marie E Migaud, Hanna E Stevens, …

Cell reports (Cambridge), Vol.26(4), pp.969-983.e4

01/22/2019

DOI: 10.1016/j.celrep.2019.01.007

PMID: 30673618

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Abstract

Conditions of metabolic stress dysregulate the NAD metabolome. By restoring NAD, nicotinamide riboside (NR) provides resistance to such conditions. We tested the hypotheses that postpartum might dysregulate maternal NAD and that increasing systemic NAD with NR might benefit mothers and offspring. In postpartum mothers, the liver NAD metabolome is depressed while blood increases circulation of NAD metabolites to enable a >20-fold increase in mammary NAD+ and NADP+. Lactation and NR synergize in stimulating prolactin synthesis and mammary biosynthetic programs. NR supplementation of new mothers increases lactation and nursing behaviors and stimulates maternal transmission of macronutrients, micronutrients, and BDNF into milk. Pups of NR-supplemented mothers are advantaged in glycemic control, size at weaning, and synaptic pruning. Adult offspring of mothers supplemented during nursing retain advantages in physical performance, anti-anxiety, spatial memory, delayed onset of behavioral immobility, and promotion of adult hippocampal neurogenesis. Thus, postgestational maternal micronutrition confers lasting advantages to offspring. [Display omitted] •Postpartum liver circulates NAD metabolites to increase mammary NAD+ and NADP+ >20-fold•NR supplementation superinduces prolactin, mammary biosynthetic programs, and lactation•Weanlings of NR-fed mothers are hypoglycemia resistant and advanced in motor learning•Adult offspring of NR-fed mothers retain striking physical and behavioral advantages Postpartum constitutes a profound episode of metabolic stress. Ear et al. show that nicotinamide riboside supplementation of rodent mothers relieves postpartum metabolic stress and increases lactation, nursing behavior, and transmission of brain-derived neurotrophic factor into milk, resulting in improved physical and neurobehavioral development of offspring, whose advantages persist into adulthood.

NAD

homeorhesis

prolactin

caudate-putamen

adult hippocampal neurogenesis

BDNF

lactation

postpartum

metabolic stress

nicotinamide riboside

Details

Title: Subtitle: Maternal Nicotinamide Riboside Enhances Postpartum Weight Loss, Juvenile Offspring Development, and Neurogenesis of Adult Offspring
Creators: Po Hien Ear - Department of Biochemistry, University of Iowa, Iowa City, IA 52242, USA
Ankita Chadda - Department of Biochemistry, University of Iowa, Iowa City, IA 52242, USA
Serena B Gumusoglu - Department of Psychiatry, University of Iowa, Iowa City, IA 52242, USA
Mark S Schmidt - Department of Biochemistry, University of Iowa, Iowa City, IA 52242, USA
Sophia Vogeler - Department of Biochemistry, University of Iowa, Iowa City, IA 52242, USA
Johnny Malicoat - Department of Biochemistry, University of Iowa, Iowa City, IA 52242, USA
Jacob Kadel - Department of Biochemistry, University of Iowa, Iowa City, IA 52242, USA
Michelle M Moore - Department of Biochemistry, University of Iowa, Iowa City, IA 52242, USA
Marie E Migaud - Department of Biochemistry, University of Iowa, Iowa City, IA 52242, USA
Hanna E Stevens - Department of Psychiatry, University of Iowa, Iowa City, IA 52242, USA
Charles Brenner - Department of Biochemistry, University of Iowa, Iowa City, IA 52242, USA
Resource Type: Journal article
Publication Details: Cell reports (Cambridge), Vol.26(4), pp.969-983.e4
DOI: 10.1016/j.celrep.2019.01.007
PMID: 30673618
NLM abbreviation: Cell Rep
ISSN: 2211-1247
eISSN: 2211-1247
Publisher: Elsevier Inc
Grant note: name: Roy J. Carver Trust; name: ChromaDex
Language: English
Date published: 01/22/2019
Academic Unit: Psychiatry; Microbiology and Immunology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Surgery; Obstetrics and Gynecology; Biochemistry and Molecular Biology; Internal Medicine
Record Identifier: 9984003454802771

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