Journal article
Maternal Weight Loss during Exclusive Breastfeeding Is Associated with Reduced Weight and Length Gain in Daughters of HIV-Infected Malawian Women
The Journal of nutrition, Vol.143(7), pp.1168-1175
07/01/2013
DOI: 10.3945/jn.112.171751
PMCID: PMC3681548
PMID: 23700341
Abstract
Maternal weight loss during exclusive breastfeeding may influence the growth of exclusively breast-fed infants through impaired quality or quantity of breast milk. This study evaluated how maternal weight loss from 2 to 24 wk postpartum was related to infant weight and length gain in 1309 lactating HIV-infected mothers and their exclusively breast-fed infants. Malawian mother-infant pairs in the Breastfeeding, Antiretrovirals, and Nutrition Study were randomized with a 2 x 3 factorial design to a 2-arm nutritional intervention with a lipid-based nutrient supplement (LNS), meeting nutritional needs of lactation, or no LNS and a 3-arm antiretroviral (ARV) intervention (maternal, infant, or no ARV regimen). Linear regression models were used to relate maternal weight loss (weight loss vs. no weight loss) to infant weight and length gain from birth to 24 mo, stratifying by gender and controlling for maternal BMI at 2 wk (mean +/- SD: 23.2 +/- 3.0 kg/m(2)) and interacting maternal BMI with weight loss. In adjusted models, compared with daughters of women who did not lose weight, length and weight gain were lower in daughters whose mothers had a lower BMI at 2 wk postpartum coupled with the weight loss. For example, among mothers with an initial BMI of 18 kg/m(2), daughters of those who lost weight gained less weight [beta = -0.29 kg (95% CI: -0.53, -0.06)] and length [beta = -0.88 cm (95% CI: -1.52, -0.23)] from birth to 24 wk than daughters of those who gained weight. Though effects were only observed in girls, suggesting possible gender differences in suckling and feeding behavior, these findings indicate that maternal weight loss with low energy reserves represents a risk factor for poor infant growth outcomes.
Details
- Title: Subtitle
- Maternal Weight Loss during Exclusive Breastfeeding Is Associated with Reduced Weight and Length Gain in Daughters of HIV-Infected Malawian Women
- Creators
- Elizabeth M. Widen - Columbia UniversityMargaret E. Bentley - University of North Carolina at Chapel HillDumbani Kayira - Univ North Carolina Project, Lilongwe, MalawiCharles S. Chasela - University of the WitwatersrandDenise J. Jamieson - Centers for Disease Control and PreventionMartin Tembo - Univ North Carolina Project, Lilongwe, MalawiAlice Soko - Univ North Carolina Project, Lilongwe, MalawiAthena P. Kourtis - Centers for Disease Control and PreventionValerie L. Flax - University of North Carolina at Chapel HillSascha R. Ellington - Centers for Disease Control and PreventionCharles M. van der Horst - University of North Carolina at Chapel HillLinda S. Adair - University of North Carolina at Chapel HillBreastfeeding, Antiretrovirals and Nutrition (BAN) study team
- Resource Type
- Journal article
- Publication Details
- The Journal of nutrition, Vol.143(7), pp.1168-1175
- Publisher
- Oxford Univ Press
- DOI
- 10.3945/jn.112.171751
- PMID
- 23700341
- PMCID
- PMC3681548
- ISSN
- 0022-3166
- eISSN
- 1541-6100
- Number of pages
- 8
- Grant note
- American Recovery and Reinvestment Act Johnson Johnson; Johnson & Johnson; Johnson & Johnson USA Elizabeth Glaser Pediatric AIDS Foundation UNICEF P30-AI50410 / University of North Carolina Center for AIDS Research World Food Program U.S. Agency for International Development; United States Agency for International Development (USAID) OPP53107 / Bill and Melinda Gates Foundation; Bill & Melinda Gates Foundation SIP 13-01 U48-CCU409660-09; SIP 26-04 U48-DP000059-01; SIP 22-09 U48-DP001944-01 / Prevention Research Centers Special Interest Project of the CDC National Institute of Allergy and Infectious Diseases; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID) 2-D43 Tw01039-06; R24 Tw00798 / NIH Fogarty AIDS International Training and Research Program (DHHS/NIH/FIC) Malawi Ministry of Health and Population
- Language
- English
- Date published
- 07/01/2013
- Academic Unit
- Obstetrics and Gynecology; VPMA - Administration
- Record Identifier
- 9984446260402771
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