Maternal alcohol binge-drinking in the first trimester and the risk of orofacial clefts in offspring: a large population-based pooling study

Lisa A DeRoo; Allen J Wilcox; Rolv T Lie; Paul A Romitti; Dorthe Almind Pedersen; Ronald G Munger; Lina M Moreno Uribe; George L Wehby

doi:10.1007/s10654-016-0171-5

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Maternal alcohol binge-drinking in the first trimester and the risk of orofacial clefts in offspring: a large population-based pooling study

Journal article

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Maternal alcohol binge-drinking in the first trimester and the risk of orofacial clefts in offspring: a large population-based pooling study

Lisa A DeRoo, Allen J Wilcox, Rolv T Lie, Paul A Romitti, Dorthe Almind Pedersen, Ronald G Munger, Lina M Moreno Uribe and George L Wehby

European journal of epidemiology, Vol.31(10), pp.1021-1034

10/2016

DOI: 10.1007/s10654-016-0171-5

PMCID: PMC5065603

PMID: 27350158

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Abstract

Using individual participant data from six population-based case-control studies, we conducted pooled analyses to examine maternal alcohol consumption and the risk of clefts among >4600 infants with cleft lip only, cleft lip with cleft palate, or cleft palate only and >10,000 unaffected controls. We examined two first-trimester alcohol measures: average number of drinks/sitting and maximum number of drinks/sitting, with five studies contributing to each analysis. Study-specific odds ratios (ORs) were estimated using logistic regression and pooled to generate adjusted summary ORs. Across studies, 0.9-3.2 % of control mothers reported drinking an average of 5+ drinks/sitting, while 1.4-23.5 % reported drinking a maximum of 5+ drinks/sitting. Compared with non-drinkers, mothers who drank an average of 5+ drinks/sitting were more likely to deliver an infant with cleft lip only (pooled OR 1.48; 95 % confidence intervals 1.01, 2.18). The estimate was higher among women who drank at this level 3+ times (pooled OR 1.95; 1.23, 3.11). Ever drinking a maximum of 5+ drinks/sitting and non-binge drinking were not associated with cleft risk. Repeated heavy maternal alcohol consumption was associated with an increased risk of cleft lip only in offspring. There was little evidence of increased risk for other cleft types or alcohol measures.

Pregnancy

Prenatal Exposure Delayed Effects - epidemiology

Humans

Middle Aged

Risk Factors

Binge Drinking - epidemiology

Young Adult

Cleft Palate - etiology

Adolescent

Adult

Female

Pregnancy Trimester, First - drug effects

Prenatal Exposure Delayed Effects - chemically induced

Binge Drinking - complications

Cleft Lip - etiology

Details

Title: Subtitle: Maternal alcohol binge-drinking in the first trimester and the risk of orofacial clefts in offspring: a large population-based pooling study
Creators: Lisa A DeRoo - Epidemiology Branch, National Institute of Environmental Health Sciences/NIH, Durham, NC, USA. Lisa.De.Roo@igs.uib.no
Allen J Wilcox - Epidemiology Branch, National Institute of Environmental Health Sciences/NIH, Durham, NC, USA
Rolv T Lie - Norwegian Institute of Public Health, Medical Birth Registry of Norway, Bergen, Norway
Paul A Romitti - Department of Epidemiology, College of Public Health, The University of Iowa, Iowa City, IA, USA
Dorthe Almind Pedersen - University of Southern Denmark
Ronald G Munger - Department of Nutrition, Dietetics, and Food Sciences, Utah State University, Logan, UT, USA
Lina M Moreno Uribe - Department of Orthodontics, College of Dentistry and Dental Clinics, The University of Iowa, Iowa City, IA, USA
George L Wehby - Department of Health Management and Policy, The University of Iowa, 105 River Street, Iowa City, IA, 52242, USA. george-wehby@uiowa.edu
Resource Type: Journal article
Publication Details: European journal of epidemiology, Vol.31(10), pp.1021-1034
DOI: 10.1007/s10654-016-0171-5
PMID: 27350158
PMCID: PMC5065603
NLM abbreviation: Eur J Epidemiol
ISSN: 1573-7284
eISSN: 1573-7284
Publisher: Netherlands
Grant note: U01 DD000492 / NCBDD CDC HHS R01 HD039061 / NICHD NIH HHS R01 DE020895 / NIDCR NIH HHS ZIA ES049027 / Intramural NIH HHS U01 DD001035 / NCBDD CDC HHS
Language: English
Date published: 10/2016
Academic Unit: Preventive and Community Dentistry; Orthodontics; Health Management and Policy; Epidemiology; Economics; Biostatistics; Craniofacial Anomalies Research Center; Public Policy Center (Archive); Dental Research
Record Identifier: 9983995011602771

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