Journal article
Maternal and Fetal Mitochondrial Gene Dysregulation in Hypertensive Disorders of Pregnancy
Physiological genomics, Vol.55(7), pp.275-285
07/2023
DOI: 10.1152/physiolgenomics.00005.2023
PMCID: PMC10292966
PMID: 37184228
Abstract
Mitochondrial dysfunction has been implicated in pregnancy-induced hypertension (PIH). The role of mitochondrial gene dysregulation in PIH, and consequences for maternal-fetal interactions, remain elusive. Here, we investigated mitochondrial gene expression and dysregulation in maternal and placental tissues from pregnancies with and without PIH; further, we measured circulating mitochondrial DNA (mtDNA) mutational load, an index of mtDNA integrity. Differential gene expression analysis followed by Time Course Gene Set Analysis (TcGSA) were conducted in publicly available high throughput sequencing transcriptomic datasets. Mutational load analysis was carried out on peripheral mononuclear blood cells from healthy pregnant individuals and individuals with preeclampsia. Thirty mitochondrial differentially expressed genes (mtDEGs) were detected in the maternal cell-free circulating transcriptome, while 9 were detected in placental transcriptome from pregnancies with PIH. In PIH pregnancies, maternal mitochondrial dysregulation was associated with pathways involved in inflammation, cell death/survival, and placental development, while fetal mitochondrial dysregulation was associated with increased production of extracellular vesicles (EVs) at term. Mothers with preeclampsia did not exhibit a significantly different degree of mtDNA mutational load. Our findings support the involvement of maternal mitochondrial dysregulation in the pathophysiology of PIH and suggest that mitochondria may mediate maternal-fetal interactions during healthy pregnancy.
Details
- Title: Subtitle
- Maternal and Fetal Mitochondrial Gene Dysregulation in Hypertensive Disorders of Pregnancy
- Creators
- Contessa A. Ricci - University of North Texas Health Science CenterDanielle M. Reid - University of North Texas Health Science CenterJie Sun - University of North Texas Health Science CenterDonna A. Santillan - University of IowaMark K. Santillan - University of IowaNicole R. Phillips - University of North Texas Health Science CenterStyliani Goulopoulou - University of North Texas Health Science Center
- Resource Type
- Journal article
- Publication Details
- Physiological genomics, Vol.55(7), pp.275-285
- DOI
- 10.1152/physiolgenomics.00005.2023
- PMID
- 37184228
- PMCID
- PMC10292966
- NLM abbreviation
- Physiol Genomics
- ISSN
- 1094-8341
- eISSN
- 1531-2267
- Grant note
- DOI: 10.13039/100000968, name: American Heart Association, award: 18SCG34350001; DOI: 10.13039/100000968, name: American Heart Association, award: 15SFRN 23730000; DOI: 10.13039/100000968, name: American Heart Association, award: 15SFRN 23480000; DOI: 10.13039/100000050, name: HHS | NIH | National Heart, Lung, and Blood Institute, award: R01HL0146562; DOI: 10.13039/100009633, name: HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development, award: R01HD089940; DOI: 10.13039/100006545, name: HHS | NIH | National Institutes on Minority Health and Health Disparities, award: U54MD006882; DOI: 10.13039/100006108, name: HHS | NIH | National Center for Advancing Translational Sciences, award: UL1TR002537; DOI: 10.13039/100015515, name: University of Iowa Carver College of Medicine
- Language
- English
- Electronic publication date
- 05/15/2023
- Date published
- 07/2023
- Academic Unit
- Obstetrics and Gynecology
- Record Identifier
- 9984410797102771
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