Journal article
Maternal and neonatal outcomes among women with HIV infection and their infants in Malawi
International journal of gynecology and obstetrics, Vol.137(3), pp.282-289
06/2017
DOI: 10.1002/ijgo.12136
PMCID: PMC5419872
PMID: 28258582
Abstract
Objective
To describe maternal and neonatal morbidity and mortality among women with HIV infection and their infants.
Methods
A secondary analysis was undertaken of data obtained in the BAN Study, a trial of postnatal antiretrovirals among pregnant women with HIV infection enrolled in 2004–2010. Mothers and infants had 13 scheduled visits through 48 weeks of follow‐up. Serious maternal morbidity and mortality were examined at delivery (n=2791), from delivery to 6 weeks later (n=2369) and from 7 to 48 weeks (n=1980). Neonatal morbidity and mortality were examined (n=2685).
Results
Of 2791 deliveries, 169 (6.1%) were by cesarean (153 emergency). Compared with women with vaginal delivery, those with cesarean delivery had lower prenatal HIV viral loads (P=0.016) and increased odds of pre‐eclampsia/eclampsia (odds ratio [OR] 10.8, 95% CI 4.4–26.8). Women with cesarean delivery also had increased odds of serious infection with 14 days of delivery (OR 3.0, 95% CI 1.3–7.4) and severe anemia (grade 3 or 4) by 6 weeks (OR 6.7, 95% CI 2.3–19.1). Infants born by cesarean had increased odds of a low 5‐minute Apgar score (OR 8.1, 95% CI 3.5–18.6) and admission to an intensive care unit (OR 5.4, 95% CI 3.7–7.8).
Conclusion
Odds of serious maternal and neonatal morbidity were higher after cesarean than vaginal delivery, despite lower maternal viral loads.
Odds of serious maternal and neonatal morbidity were higher after cesarean than vaginal delivery, despite lower maternal viral loads.
Details
- Title: Subtitle
- Maternal and neonatal outcomes among women with HIV infection and their infants in Malawi
- Creators
- Michelle S. Chevalier - Center for Global HealthCaroline C. King - Centers for Disease Control and PreventionSascha Ellington - National Center for Chronic Disease Prevention and Health PromotionJeffrey Wiener - Centers for Disease Control and PreventionDumbani Kayira - University of MalawiCharles S. Chasela - Human Sciences Research CouncilDenise J. Jamieson - National Center for Chronic Disease Prevention and Health PromotionAthena P. Kourtis - Centers for Disease Control and Prevention
- Resource Type
- Journal article
- Publication Details
- International journal of gynecology and obstetrics, Vol.137(3), pp.282-289
- DOI
- 10.1002/ijgo.12136
- PMID
- 28258582
- PMCID
- PMC5419872
- ISSN
- 0020-7292
- eISSN
- 1879-3479
- Number of pages
- 9
- Grant note
- Carolina Population Center (R24 HD050924) Bristol‐Myers Squibb Elizabeth Glaser Pediatric AIDS Foundation US Agency for International Development University of North Carolina Center for AIDS Research (P30‐AI50410) Fogarty FICRS (R24TW007988) Johnson and Johnson Bill & Melinda Gates Foundation (OPP53107) National Institute of Allergy and Infectious Diseases Prevention Research Centers Special Interest Project of the Centers for Disease Control and Prevention (SIP 13‐01 U48‐CCU409660‐09; SIP 26‐04 U48‐DP000059‐01; SIP 22‐09 U48‐DP001944‐01) GlaxoSmithKline National Institutes for Health Fogarty AIDS International Training and Research Program (DHHS/NIH/FIC 2‐D43 TW001039) Abbott Laboratories World Food Program Malawi Ministry of Health and Population Boehringer Ingelheim Roche Pharmaceuticals United Nations Children's Fund
- Language
- English
- Date published
- 06/2017
- Academic Unit
- Obstetrics and Gynecology; VPMA - Administration
- Record Identifier
- 9984446409502771
Metrics
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