Maternal caffeine consumption and risk of cardiovascular malformations

Marilyn L Browne; Charlotte M Druschel; Lenore J Gensburg; Allen A Mitchell; Erin M Bell; Angela E Lin; Paul A Romitti; Adolfo Correa; National Birth Defects Prevention Study

doi:10.1002/bdra.20365

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Maternal caffeine consumption and risk of cardiovascular malformations

Journal article

Peer reviewed

Maternal caffeine consumption and risk of cardiovascular malformations

Marilyn L Browne, Charlotte M Druschel, Lenore J Gensburg, Allen A Mitchell, Erin M Bell, Angela E Lin, Paul A Romitti, Adolfo Correa and National Birth Defects Prevention Study

Birth defects research. A Clinical and molecular teratology, Vol.79(7), pp.533-543

07/2007

DOI: 10.1002/bdra.20365

PMID: 17405163

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Abstract

The physiologic effects and common use of caffeine during pregnancy call for examination of maternal caffeine consumption and risk of birth defects. Epidemiologic studies have yielded mixed results, but such studies have grouped etiologically different defects and have not evaluated effect modification. The large sample size and precise case classification of the National Birth Defects Prevention Study allowed us to examine caffeine consumption and specific cardiovascular malformation (CVM) case groups. We studied consumption of caffeinated coffee, tea, soda, and chocolate to estimate total caffeine intake and separately examined exposure to each caffeinated beverage. Smoking, alcohol, vasoactive medications, folic acid supplement use, and infant gender were evaluated for effect modification. Maternal interview reports for 4,196 CVM case infants overall and 3,957 control infants were analyzed. We did not identify any significant positive associations between maternal caffeine consumption and CVMs. For tetralogy of Fallot, nonsignificant elevations in risk were observed for moderate (but not high) caffeine intake overall and among nonsmokers (ORs of 1.3 to 1.5). Risk estimates for both smoking and consuming caffeine were less than the sum of the excess risks for each exposure. We observed an inverse trend between coffee intake and risk of atrial septal defect; however, this single significant pattern of association might have been a chance finding. Our study found no evidence for an appreciable teratogenic effect of caffeine with regard to CVMs.

Pregnancy

United States - epidemiology

Caffeine - administration & dosage

Risk Assessment

Humans

Case-Control Studies

Adolescent

Adult

Female

Central Nervous System Stimulants - administration & dosage

Child

Infant, Newborn

Cardiovascular Abnormalities - epidemiology

Details

Title: Subtitle: Maternal caffeine consumption and risk of cardiovascular malformations
Creators: Marilyn L Browne - Bureau of Environmental & Occupational Epidemiology, New York State Department of Health, Troy, New York, USA. mlb10@health.state.ny.us
Charlotte M Druschel
Lenore J Gensburg
Allen A Mitchell
Erin M Bell - University at Albany, State University of New York
Angela E Lin
Paul A Romitti
Adolfo Correa
National Birth Defects Prevention Study
Resource Type: Journal article
Publication Details: Birth defects research. A Clinical and molecular teratology, Vol.79(7), pp.533-543
DOI: 10.1002/bdra.20365
PMID: 17405163
NLM abbreviation: Birth Defects Res A Clin Mol Teratol
ISSN: 1542-0752
eISSN: 1542-0760
Publisher: Wiley; United States
Grant note: U50/CCU0223184 / PHS HHS
Language: English
Date published: 07/2007
Academic Unit: Epidemiology; Biostatistics
Record Identifier: 9983995178602771

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