Maternal caffeine consumption and small for gestational age births: results from a population-based case-control study

Adrienne T Hoyt; Marilyn Browne; Sandra Richardson; Paul Romitti; Charlotte Druschel; National Birth Defects Prevention Study

doi:10.1007/s10995-013-1397-4

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Maternal caffeine consumption and small for gestational age births: results from a population-based case-control study

Journal article

Peer reviewed

Maternal caffeine consumption and small for gestational age births: results from a population-based case-control study

Adrienne T Hoyt, Marilyn Browne, Sandra Richardson, Paul Romitti, Charlotte Druschel and National Birth Defects Prevention Study

Maternal and child health journal, Vol.18(6), pp.1540-1551

08/2014

DOI: 10.1007/s10995-013-1397-4

PMCID: PMC5896301

PMID: 24288144

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Abstract

Caffeine is consumed in various forms during pregnancy, has increased half-life during pregnancy and crosses the placental barrier. Small for gestational age (SGA) is an important perinatal outcome and has been associated with long term complications. We examined the association between maternal caffeine intake and SGA using National Birth Defects Prevention Study data. Non-malformed live born infants with an estimated date of delivery from 1997-2007 (n = 7,943) were included in this analysis. Maternal caffeine exposure was examined as total caffeine intake and individual caffeinated beverage type (coffee, tea, and soda); sex-, race/ethnic-, and parity-specific growth curves were constructed to estimate SGA births. Crude and adjusted odds ratios (aORs) and 95% confidence intervals were estimated using unconditional logistic regression. Interaction with caffeine exposures was assessed for maternal smoking, vasoconstrictor medication use, and folic acid. Six hundred forty-eight infants (8.2%) were found to be SGA in this analysis. Increasing aORs were observed for increasing intakes of total caffeine and for each caffeinated beverage with aORs (adjusting for maternal education, high blood pressure, and smoking) ranging from 1.3 to 2.1 for the highest intake categories (300+ mg/day total caffeine and 3+ servings/day for each beverage type). Little indication of additive interaction by maternal smoking, vasoconstrictor medication use, or folic acid intake was observed. We observed an increase in SGA births for mothers with higher caffeine intake, particularly for those consuming 300+ mg of caffeine per day. Increased aORs were also observed for tea intake but were more attenuated for coffee and soda intake.

Humans

Caffeine - adverse effects

Tea - adverse effects

Male

Carbonated Beverages - adverse effects

Case-Control Studies

Pregnancy

Young Adult

Central Nervous System Stimulants - adverse effects

Infant, Small for Gestational Age - metabolism

Adolescent

Adult

Female

Coffee - adverse effects

Infant, Newborn

Details

Title: Subtitle: Maternal caffeine consumption and small for gestational age births: results from a population-based case-control study
Creators: Adrienne T Hoyt - Birth Defects Epidemiology and Surveillance Branch, Texas Center for Birth Defects Research and Prevention, Texas Department of State Health Services, PO Box 149347, MC 1964, Austin, TX, 78714-9347, USA, adrienne.hoyt@dshs.state.tx.us
Marilyn Browne
Sandra Richardson
Paul Romitti
Charlotte Druschel
National Birth Defects Prevention Study
Resource Type: Journal article
Publication Details: Maternal and child health journal, Vol.18(6), pp.1540-1551
DOI: 10.1007/s10995-013-1397-4
PMID: 24288144
PMCID: PMC5896301
NLM abbreviation: Matern Child Health J
ISSN: 1573-6628
eISSN: 1573-6628
Publisher: Springer Science and Business Media LLC; United States
Grant note: U01 DD000492 / NCBDD CDC HHS U01 DD000494 / NCBDD CDC HHS U01-DD00048702 / NCBDD CDC HHS U01-DD000494 / NCBDD CDC HHS
Language: English
Date published: 08/2014
Academic Unit: Epidemiology; Biostatistics
Record Identifier: 9983995058802771

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