Maternal characteristics and pregnancy outcomes after assisted reproductive technology by infertility diagnosis: ovulatory dysfunction versus tubal obstruction

Violanda Grigorescu; Yujia Zhang; Dmitry M. Kissin; Erin Sauber-Schatz; Mithi Sunderam; Russell S. Kirby; Hafsatou Diop; Patricia McKane; Denise J. Jamieson

doi:10.1016/j.fertnstert.2013.12.030

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Maternal characteristics and pregnancy outcomes after assisted reproductive technology by infertility diagnosis: ovulatory dysfunction versus tubal obstruction

Journal article

Open access

Peer reviewed

Maternal characteristics and pregnancy outcomes after assisted reproductive technology by infertility diagnosis: ovulatory dysfunction versus tubal obstruction

Violanda Grigorescu, Yujia Zhang, Dmitry M. Kissin, Erin Sauber-Schatz, Mithi Sunderam, Russell S. Kirby, Hafsatou Diop, Patricia McKane and Denise J. Jamieson

Fertility and sterility, Vol.101(4), pp.1019-1025

04/01/2014

DOI: 10.1016/j.fertnstert.2013.12.030

PMCID: PMC4701028

PMID: 24484993

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Abstract

To examine differences in maternal characteristics and pregnancy outcomes between women with ovulatory dysfunction (OD) and women with tubal obstruction (TO) who underwent assisted reproductive technology (ART). Retrospective cohort study. Centers for Disease Control and Prevention. Exposed and nonexposed groups were selected from the 2000–2006 National ART Surveillance System linked with live-birth certificates from three states: Florida, Massachusetts, and Michigan. None. Maternal characteristics and pregnancy outcomes, including newborn's health status right after delivery (Apgar score, <7 vs. ≥7) as the study outcome of interest, were assessed among women with OD/polycystic ovary syndrome (PCOS) and TO who used ART. A significantly higher prevalence of women with OD/PCOS were younger (<35 years of age; 65.7% vs. 48.9%), were white (85.4% vs. 74.4%), had higher education (29.4% vs. 15.6%), and experienced diabetes (8.8% vs. 5.3%) compared with those having TO. The odds of having a lower (<7) Apgar score at 5 minutes were almost twice as high among newborns of women with OD/PCOS compared with those with TO (crude odds ratio, 1.86; 95% confidence interval [CI], 1.31, 2.64; adjusted odds ratio, 1.90; 95% CI, 1.30, 2.77). Women with OD/PCOS who underwent ART have different characteristics and health issues (higher prevalence of diabetes) and infant outcomes (lower Apgar score) compared with women with TO.

Apgar score

assisted reproductive technology (ART)

Ovulatory dysfunction (OD)

polycystic ovary syndrome (PCOS)

tubal obstruction (TO)

Details

Title: Subtitle: Maternal characteristics and pregnancy outcomes after assisted reproductive technology by infertility diagnosis: ovulatory dysfunction versus tubal obstruction
Creators: Violanda Grigorescu - Centers for Disease Control and Prevention
Yujia Zhang - Centers for Disease Control and Prevention
Dmitry M. Kissin - Centers for Disease Control and Prevention
Erin Sauber-Schatz - Centers for Disease Control and Prevention
Mithi Sunderam - Centers for Disease Control and Prevention
Russell S. Kirby - University of South Florida
Hafsatou Diop - Massachusetts Department of Public Health
Patricia McKane - Michigan Department of Health and Human Services
Denise J. Jamieson - Centers for Disease Control and Prevention
Resource Type: Journal article
Publication Details: Fertility and sterility, Vol.101(4), pp.1019-1025
DOI: 10.1016/j.fertnstert.2013.12.030
PMID: 24484993
PMCID: PMC4701028
NLM abbreviation: Fertil Steril
ISSN: 0015-0282
eISSN: 1556-5653
Publisher: Elsevier Inc
Grant note: March of Dimes Centers for Disease Control and Prevention state of Florida
Language: English
Date published: 04/01/2014
Academic Unit: Obstetrics and Gynecology; VPMA - Administration
Record Identifier: 9984446530902771

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