Maternal corticosteroid use and orofacial clefts

Suzan L Carmichael; Gary M Shaw; Chen Ma; Martha M Werler; Sonja A Rasmussen; Edward J Lammer; National Birth Defects Prevention Study

doi:10.1016/j.ajog.2007.05.046

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Maternal corticosteroid use and orofacial clefts

Journal article

Peer reviewed

Maternal corticosteroid use and orofacial clefts

Suzan L Carmichael, Gary M Shaw, Chen Ma, Martha M Werler, Sonja A Rasmussen, Edward J Lammer and National Birth Defects Prevention Study

American journal of obstetrics and gynecology, Vol.197(6), pp.585.e1-585.e7

12/2007

DOI: 10.1016/j.ajog.2007.05.046

PMID: 18060943

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Abstract

The purpose of this study was to examine whether maternal corticosteroid use during pregnancy is associated with delivering an infant with an orofacial cleft. This study included data on deliveries from the National Birth Defects Prevention Study, which is a population-based case-control study. Exposures were assessed by telephone interviews for mothers of 1141 cases with cleft lip +/- cleft palate (CLP), 628 with cleft palate (CP), and 4143 controls. Mothers of 33 infants with CLP (2.9%), mothers of 6 infants with CP (1.0%), and 72 control subjects (1.7%) reported corticosteroid use from 4 weeks before through 12 weeks after conception. The crude odds ratio for "any" vs "no" use was 1.7 (95% CI, 1.1-2.6) for CLP and 0.5 (0.2-1.3) for CP. When analyzed by route of administration and medication components, odds ratios for CLP tended to be elevated, and odds ratios for CP tended to be close to 1. Our results suggest a moderately increased risk of CLP among women who use corticosteroids during early pregnancy.

Pregnancy

Case-Control Studies

Cleft Lip - chemically induced

Cleft Palate - chemically induced

Female

Glucocorticoids - adverse effects

Humans

Infant, Newborn

Interviews as Topic

Prenatal Exposure Delayed Effects

Details

Title: Subtitle: Maternal corticosteroid use and orofacial clefts
Creators: Suzan L Carmichael - March of Dimes Foundation/California Department of Health Services, California Birth Defects Monitoring Program, Berkeley, CA, USA. SCarmichael@marchofdimes.com
Gary M Shaw
Chen Ma
Martha M Werler
Sonja A Rasmussen
Edward J Lammer
National Birth Defects Prevention Study
Contributors: Paul A Romitti (Contributor) - University of Iowa, Epidemiology
Resource Type: Journal article
Publication Details: American journal of obstetrics and gynecology, Vol.197(6), pp.585.e1-585.e7
DOI: 10.1016/j.ajog.2007.05.046
PMID: 18060943
NLM abbreviation: Am J Obstet Gynecol
ISSN: 0002-9378
eISSN: 1097-6868
Grant note: U50/CCU913241 / PHS HHS
Language: English
Date published: 12/2007
Academic Unit: Epidemiology; Biostatistics
Record Identifier: 9984214727902771

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