Journal article
Maternal diabetes and the risk of autism spectrum disorders in the offspring: a systematic review and meta-analysis
Journal of autism and developmental disorders, Vol.44(4), pp.766-775
04/2014
DOI: 10.1007/s10803-013-1928-2
PMCID: PMC4181720
PMID: 24057131
Abstract
We performed a systematic literature search regarding maternal diabetes before and during pregnancy and the risk of autism spectrum disorders (ASD) in the offspring. Of the 178 potentially relevant articles, 12 articles including three cohort studies and nine case-control studies were included in the meta-analysis. Both the meta-analyses of cohort studies and case-control studies showed significant associations. The pooled relative risk and 95% confidence interval (CI) among cohort studies was 1.48 (1.25-1.75, p < 0.001). For case-control studies, the pooled odds ratio and 95% CI was 1.72 (1.24-2.41, p = 0.001). No indication of significant heterogeneity across studies or publication bias was observed. In conclusion, maternal diabetes was significantly associated with a greater risk of ASD in the offspring.
Details
- Title: Subtitle
- Maternal diabetes and the risk of autism spectrum disorders in the offspring: a systematic review and meta-analysis
- Creators
- Guifeng Xu - Department of Maternal and Child Health, School of Public Health, Sun Yat-Sen University, Guangzhou, 510080, ChinaJin JingKatherine BowersBuyun LiuWei Bao
- Resource Type
- Journal article
- Publication Details
- Journal of autism and developmental disorders, Vol.44(4), pp.766-775
- DOI
- 10.1007/s10803-013-1928-2
- PMID
- 24057131
- PMCID
- PMC4181720
- NLM abbreviation
- J Autism Dev Disord
- ISSN
- 0162-3257
- eISSN
- 1573-3432
- Publisher
- United States
- Grant note
- Intramural NIH HHS
- Language
- English
- Date published
- 04/2014
- Academic Unit
- Stead Family Department of Pediatrics; Epidemiology; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9983995055002771
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