Journal article
Maternal dietary intake of nitrates, nitrites and nitrosamines and selected birth defects in offspring: a case-control study
Nutrition journal, Vol.12(1), pp.34-34
03/21/2013
DOI: 10.1186/1475-2891-12-34
PMCID: PMC3607976
PMID: 23514444
Abstract
Dietary intake of nitrates, nitrites, and nitrosamines can increase the endogenous formation of N-nitroso compounds in the stomach. Results from animal studies suggest that these compounds might be teratogenic. We examined the relationship between maternal dietary intake of nitrates, nitrites (including plant and animal sources as separate groups), and nitrosamines and several types of birth defects in offspring.
For this population-based case-control study, data from a 58-question food frequency questionnaire, adapted from the short Willett Food Frequency Questionnaire and administered as part of the National Birth Defects Prevention Study (NBDPS), were used to estimate daily intake of dietary nitrates, nitrites, and nitrosamines in a sample of 6544 mothers of infants with neural tube defects (NTD)s, oral clefts (OC)s, or limb deficiencies (LD)s and 6807 mothers of unaffected control infants. Total daily intake of these compounds was divided into quartiles based on the control mother distributions. Odds ratios (OR)s and 95% confidence intervals (CI)s were estimated using logistic regression; estimates were adjusted for maternal daily caloric intake, maternal race-ethnicity, education, dietary folate intake, high fat diet (>30% of calories from fat), and state of residence.
While some unadjusted ORs for NTDS had 95% (CI)s that excluded the null value, none remained significant after adjustment for covariates, and the effect sizes were small (adjusted odds ratios [aOR]<1.12). Similar results were found for OCs and LDs with the exception of animal nitrites and cleft lip with/without cleft palate (aORs and CIs for quartile 4 compared to quartile 1 =1.24; CI=1.05-1.48), animal nitrites and cleft lip (4th quartile aOR=1.32; CI=1.01-1.72), and total nitrite and intercalary LD (4th quartile aOR=4.70; CI=1.23-17.93).
Overall, odds of NTDs, OCs or LDs did not appear to be significantly associated with estimated dietary intake of nitrate, nitrite, and nitrosamines.
Details
- Title: Subtitle
- Maternal dietary intake of nitrates, nitrites and nitrosamines and selected birth defects in offspring: a case-control study
- Creators
- John C Huber Jr - Department of Epidemiology and Biostatistics, The Texas A&M Health Science Center School of Rural Public Health, MS 1266 TAMU, College Station, TX 77843-1266, USA. jdbrender@srph.tamhsc.eduJean D BrenderQi ZhengJoseph R SharkeyAnn M VuongMayura U ShindeJohn S GriesenbeckLucina SuarezPeter H LangloisMark A CanfieldPaul A RomittiPeter J WeyerNational Birth Defects Prevention Study
- Resource Type
- Journal article
- Publication Details
- Nutrition journal, Vol.12(1), pp.34-34
- DOI
- 10.1186/1475-2891-12-34
- PMID
- 23514444
- PMCID
- PMC3607976
- NLM abbreviation
- Nutr J
- ISSN
- 1475-2891
- eISSN
- 1475-2891
- Publisher
- England
- Grant note
- U50/CCU613232 / PHS HHS P30 ES005605 / NIEHS NIH HHS 3R01ES015634-03S1 / NIEHS NIH HHS 5R01ES015634 / NIEHS NIH HHS
- Language
- English
- Date published
- 03/21/2013
- Academic Unit
- Occupational and Environmental Health; Epidemiology; Biostatistics
- Record Identifier
- 9983995009502771
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