Journal article
Maternal dyslipidemia and risk for preterm birth
PloS one, Vol.13(12), pp.e0209579-e0209579
2018
DOI: 10.1371/journal.pone.0209579
PMCID: PMC6303099
PMID: 30576377
Abstract
Maternal lipid profiles during pregnancy are associated with risk for preterm birth. This study investigates the association between maternal dyslipidemia and subsequent preterm birth among pregnant women in the state of California. Births were identified from California birth certificate and hospital discharge records from 2007-2012 (N = 2,865,987). Preterm birth was defined as <37 weeks completed gestation and dyslipidemia was defined by diagnostic codes. Subtypes of preterm birth were classified as preterm premature rupture of membranes (PPROM), spontaneous labor, and medically indicated, according to birth certificate data and diagnostic codes. The association between dyslipidemia and preterm birth was tested with logistic regression. Models were adjusted for maternal age at delivery, race/ethnicity, hypertension, pre-pregnancy body mass index, insurance type, and education. Maternal dyslipidemia was significantly associated with increased odds of preterm birth (adjusted OR: 1.49, 95%CI: 1.39, 1.59). This finding was consistent across all subtypes of preterm birth, including PPROM (adjusted OR: 1.54, 95%CI: 1.34, 1.76), spontaneous (adjusted OR: 1.51, 95%CI: 1.39, 1.65), and medically indicated (adjusted OR: 1.454, 95%CI: 1.282, 1.649). This study suggests that maternal dyslipidemia is associated with increased risk for all types of preterm birth.
Details
- Title: Subtitle
- Maternal dyslipidemia and risk for preterm birth
- Creators
- Caitlin J Smith - Department of Epidemiology, University of Iowa, Iowa City, Iowa, United States of AmericaRebecca J Baer - California Preterm Birth Initiative, University of California San Francisco, San Francisco, California, United States of AmericaScott P Oltman - Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, United States of AmericaPatrick J Breheny - Department of Biostatistics, University of Iowa, Iowa City, Iowa, United States of AmericaWei Bao - Department of Epidemiology, University of Iowa, Iowa City, Iowa, United States of AmericaJennifer G Robinson - Department of Epidemiology, University of Iowa, Iowa City, Iowa, United States of AmericaJohn M Dagle - Department of Pediatrics, University of Iowa, Iowa City, Iowa, United States of AmericaLiang Liang - Department of Genetics, Stanford University, Stanford, California, United States of AmericaSky K Feuer - Department of Obstetrics, Gynecology & Reproductive Sciences, University of California San Francisco, San Francisco, California, United States of AmericaChristina D Chambers - Department of Pediatrics, University of California San Diego, La Jolla, California, United States of AmericaLaura L Jelliffe-Pawlowski - Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, United States of AmericaKelli K Ryckman - Department of Pediatrics, University of Iowa, Iowa City, Iowa, United States of America
- Resource Type
- Journal article
- Publication Details
- PloS one, Vol.13(12), pp.e0209579-e0209579
- DOI
- 10.1371/journal.pone.0209579
- PMID
- 30576377
- PMCID
- PMC6303099
- NLM abbreviation
- PLoS One
- ISSN
- 1932-6203
- eISSN
- 1932-6203
- Publisher
- United States
- Grant note
- T32 AR064194 / NIAMS NIH HHS
- Language
- English
- Date published
- 2018
- Academic Unit
- Stead Family Department of Pediatrics; Epidemiology; Biostatistics; Fraternal Order of Eagles Diabetes Research Center; Biochemistry and Molecular Biology; Neonatology; Internal Medicine
- Record Identifier
- 9983995048302771
Metrics
29 Record Views