Journal article
Maternal factors and complications of preterm birth associated with neonatal thyroid stimulating hormone
Journal of pediatric endocrinology & metabolism : JPEM, Vol.27(9-10), pp.929-938
09/2014
DOI: 10.1515/jpem-2013-0366
PMCID: PMC4260397
PMID: 24854527
Abstract
Thyroid hormones are important regulators of fetal neurodevelopment. Among preterm infants, thyroid stimulating hormone (TSH) is highly variable. Understanding this variability will further improvements in screening for thyroid disorders in preterm infants. We examined 61 maternal and infant clinical and demographic factors for associations with neonatal TSH levels in 698 preterm neonates. TSH was measured as part of routine State-mandated newborn screening in Iowa. Of the maternal characteristics, nulliparous women (p=8×10-4), women with preeclampsia (p=2×10-3), and those with induced labor (p=3×10-3) had infants with higher TSH levels. TSH levels at the time of newborn screening were associated with respiratory distress syndrome (RDS) (p<0.0001) and sepsis (p=3×10-3). We replicated findings between parity and preeclampsia previously observed in primarily term infants. We also observed strong relationships between neonatal TSH and complications of prematurity including RDS and sepsis, which have implications for future studies examining this relationship both prenatally and longitudinally after birth.
Details
- Title: Subtitle
- Maternal factors and complications of preterm birth associated with neonatal thyroid stimulating hormone
- Creators
- Kelli K RyckmanCassandra N SpracklenJohn M DagleJeffrey C Murray
- Resource Type
- Journal article
- Publication Details
- Journal of pediatric endocrinology & metabolism : JPEM, Vol.27(9-10), pp.929-938
- DOI
- 10.1515/jpem-2013-0366
- PMID
- 24854527
- PMCID
- PMC4260397
- NLM abbreviation
- J Pediatr Endocrinol Metab
- ISSN
- 0334-018X
- eISSN
- 2191-0251
- Publisher
- Germany
- Grant note
- R01 HD052953 / NICHD NIH HHS R01 HD-52953 / NICHD NIH HHS R00 HD-065786 / NICHD NIH HHS R00 HD065786 / NICHD NIH HHS K99 HD065786 / NICHD NIH HHS R01 HD057192 / NICHD NIH HHS R01 HD-57192 / NICHD NIH HHS
- Language
- English
- Date published
- 09/2014
- Academic Unit
- Anatomy and Cell Biology; International Programs; Stead Family Department of Pediatrics; Epidemiology; Pediatric Dentistry; Craniofacial Anomalies Research Center; Nursing; Public Policy Center (Archive); Biochemistry and Molecular Biology; Dental Research; Neonatology
- Record Identifier
- 9983995164702771
Metrics
33 Record Views