Maternal fever during early pregnancy and the risk of oral clefts

S. Shahrukh Hashmi; M Shayne Gallaway; D Kim Waller; Peter H Langlois; Jacqueline T Hecht; National Birth Defects Prevention Study

doi:10.1002/bdra.20646

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Maternal fever during early pregnancy and the risk of oral clefts

Journal article

Peer reviewed

Maternal fever during early pregnancy and the risk of oral clefts

S. Shahrukh Hashmi, M Shayne Gallaway, D Kim Waller, Peter H Langlois, Jacqueline T Hecht and National Birth Defects Prevention Study

Birth defects research. A Clinical and molecular teratology, Vol.88(3), pp.186-194

03/2010

DOI: 10.1002/bdra.20646

PMID: 20099315

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Abstract

An increased risk of birth defects after hyperthermic exposures has been confirmed in animal studies, but population studies have yielded inconsistent results. Oral clefts are a common birth defect and have been associated with these exposures in some of these studies. In this study, data from the National Birth Defects Prevention Study was used to evaluate the association of maternal report of febrile illness in early pregnancy and the risk of oral clefts. All oral cleft cases born between 1997 and 2004 were compared with nonmalformed controls born in the same geographical region during the same time period. Mothers reporting febrile illness during pregnancy were stratified by fever grade and antipyretic use. Logistic regression models were used to generate crude and adjusted odds ratios for exposure to fever and association with each oral cleft phenotype. The dataset included 5821 controls, 1567 cases of cleft lip with or without cleft palate (CL+/-P) and 835 cases of cleft palate only. A modestly increased risk was observed for isolated CL+/-P (odds ratio, 1.28; 95% confidence interval, 1.01-1.63). Stratification by fever grade (body temperature <101.5 degrees or > or =101.5 degrees F) did not yield significant differences in risk. Risk estimates were higher among women who reported a fever, but did not take antipyretics to control their fever, particularly for nonisolated compared with isolated oral clefts. This finding suggests that adequate control of fever may diminish the deleterious effects of fever in cases of oral cleft.

Pregnancy

Abnormalities, Multiple - embryology

Abnormalities, Multiple - epidemiology

Abnormalities, Multiple - etiology

Adolescent

Adult

Analgesics, Non-Narcotic - therapeutic use

Cleft Lip - embryology

Cleft Lip - epidemiology

Cleft Lip - etiology

Cleft Palate - embryology

Cleft Palate - epidemiology

Cleft Palate - etiology

Female

Fever - drug therapy

Fever - epidemiology

Fever - physiopathology

Humans

Odds Ratio

Parity

Pregnancy Complications, Infectious - epidemiology

Pregnancy Complications, Infectious - physiopathology

Pregnancy Outcome

United States - epidemiology

Young Adult

Details

Title: Subtitle: Maternal fever during early pregnancy and the risk of oral clefts
Creators: S. Shahrukh Hashmi - The University of Texas Medical School at Houston, Houston, Texas 77030, USA. syed.s.hashmi.1@uth.tmc.edu
M Shayne Gallaway
D Kim Waller
Peter H Langlois
Jacqueline T Hecht
National Birth Defects Prevention Study
Contributors: Paul A Romitti (Contributor) - University of Iowa, Epidemiology
Resource Type: Journal article
Publication Details: Birth defects research. A Clinical and molecular teratology, Vol.88(3), pp.186-194
DOI: 10.1002/bdra.20646
PMID: 20099315
NLM abbreviation: Birth Defects Res A Clin Mol Teratol
ISSN: 1542-0752
eISSN: 1542-0760
Publisher: Wiley
Grant note: U50/CCU613232 / PHS HHS
Language: English
Date published: 03/2010
Academic Unit: Epidemiology; Biostatistics
Record Identifier: 9984214820102771

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