Journal article
Maternal gut microbiome regulates immunity to RSV infection in offspring
The Journal of experimental medicine, Vol.218(11), e20210235
11/01/2021
DOI: 10.1084/jem.20210235
PMCID: PMC8500238
PMID: 34613328
Abstract
Development of the immune system can be influenced by diverse extrinsic and intrinsic factors that influence the risk of disease. Severe early life respiratory syncytial virus (RSV) infection is associated with persistent immune alterations. Previously, our group had shown that adult mice orally supplemented with Lactobacillus johnsonii exhibited decreased airway immunopathology following RSV infection. Here, we demonstrate that offspring of mice supplemented with L. johnsonii exhibit reduced airway mucus and Th2 cell-mediated response to RSV infection. Maternal supplementation resulted in a consistent gut microbiome in mothers and their offspring. Importantly, supplemented maternal plasma and breastmilk, and offspring plasma, exhibited decreased inflammatory metabolites. Cross-fostering studies showed that prenatal Lactobacillus exposure led to decreased Th2 cytokines and lung inflammation following RSV infection, while postnatal Lactobacillus exposure diminished goblet cell hypertrophy and mucus production in the lung in response to airway infection. These studies demonstrate that Lactobacillus modulation of the maternal microbiome and associated metabolic reprogramming enhance airway protection against RSV in neonates.
Details
- Title: Subtitle
- Maternal gut microbiome regulates immunity to RSV infection in offspring
- Creators
- Wendy Fonseca - University of Michigan–Ann ArborCarrie-Anne Malinczak - University of Michigan–Ann ArborKei Fujimura - University of California, San FranciscoDanny Li - University of California, San FranciscoKathryn McCauley - University of California, San FranciscoJia Li - Henry Ford Health SystemShannon K K Best - University of Michigan–Ann ArborDiana Zhu - University of Michigan–Ann ArborAndrew J Rasky - University of Michigan–Ann ArborChristine C Johnson - Henry Ford Health SystemJennifer Bermick - University of Michigan–Ann ArborEdward M Zoratti - Henry Ford Health SystemDennis Ownby - Augusta UniversitySusan V Lynch - University of California, San FranciscoNicholas W Lukacs - University of Michigan–Ann ArborCatherine Ptaschinski - University of Michigan–Ann Arbor
- Resource Type
- Journal article
- Publication Details
- The Journal of experimental medicine, Vol.218(11), e20210235
- DOI
- 10.1084/jem.20210235
- PMID
- 34613328
- PMCID
- PMC8500238
- ISSN
- 0022-1007
- eISSN
- 1540-9538
- Grant note
- PO1AI1089473 / NIH HHS T32 HL007517 / NHLBI NIH HHS R01 AI138348 / NIAID NIH HHS
- Language
- English
- Date published
- 11/01/2021
- Academic Unit
- Stead Family Department of Pediatrics; Neonatology
- Record Identifier
- 9984353925702771
Metrics
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