Journal article
Maternal high-fat diet acts on the brain to induce baroreflex dysfunction and sensitization of angiotensin II-induced hypertension in adult offspring
American journal of physiology. Heart and circulatory physiology, Vol.314(5), pp.H1061-H1069
05/01/2018
DOI: 10.1152/ajpheart.00698.2017
PMCID: PMC6008148
PMID: 29373045
Abstract
Accumulating evidence indicates that maternal high-fat diet (HFD) is associated with metabolic syndrome and cardiovascular disease in adult offspring. The present study tested the hypothesis that maternal HFD modulates the brain renin-angiotensin system (RAS), oxidative stress, and proinflammatory cytokines that alter angiotensin II (ANG II) and TNF-α actions and sensitize the ANG II-elicited hypertensive response in adult offspring. All offspring were cross fostered by dams on the same or opposite diet to yield the following four groups: offspring from normal-fat control diet-fed dams suckled by control diet-fed dams (OCC group) or by HFD-fed dams (OCH group) and offspring from HFD-fed dams fed a HFD suckled by control diet-fed dams (OHC group) or by HFD-fed dams (OHH group). RT-PCR analyses of the lamina terminalis and paraventricular nucleus indicated upregulation of mRNA expression of several RAS components, NADPH oxidase, and proinflammatory cytokines in 10-wk-old male offspring of dams fed a HFD during either pregnancy, lactation, or both (OHC, OCH, and OHH groups). These offspring also showed decreased cardiac baroreflex sensitivity and increased pressor responses to intracerebroventricular microinjection of either ANG II or TNF-α. Furthermore, chronic systemic infusion of ANG II resulted in enhanced upregulation of mRNA expression of RAS components, NADPH oxidase, and proinflammatory cytokines in the lamina terminalis and paraventricular nucleus and an augmented hypertensive response in the OHC, OCH, and OHH groups compared with the OCC group. The results suggest that maternal HFD blunts cardiac baroreflex function and enhances pressor responses to ANG II or proinflammatory cytokines through upregulation of the brain RAS, oxidative stress, and inflammation. NEW & NOTEWORTHY The results of our study indicate that a maternal high-fat diet during either pregnancy or lactation is sufficient for perinatal programming of sensitization for hypertension, which is associated with hyperreactivity of central cardiovascular nuclei that, in all likelihood, involves elevated expression of the renin-angiotensin system, NADPH oxidase, and proinflammatory cytokines. The present study demonstrates, for the first time, the central mechanism underlying maternal high-fat diet sensitization of the hypertensive response in adult offspring.
Details
- Title: Subtitle
- Maternal high-fat diet acts on the brain to induce baroreflex dysfunction and sensitization of angiotensin II-induced hypertension in adult offspring
- Creators
- Yu-Ping Zhang - Life Science Research CenterYan-Li Huo - Life Science Research CenterZhi-Qin Fang - First Affiliated Hospital, Hebei North University, Zhangjiakou City, Hebei , ChinaXue-Fang Wang - Life Science Research CenterHai-Ping Wang - Life Science Research CenterJian-Dong Li - Life Science Research CenterWei Peng - Life Science Research CenterAlan Kim Johnson - Department of Psychological and Brain Sciences, University of Iowa , Iowa City, IowaBaojian Xue - Department of Psychological and Brain Sciences, University of Iowa , Iowa City, Iowa
- Resource Type
- Journal article
- Publication Details
- American journal of physiology. Heart and circulatory physiology, Vol.314(5), pp.H1061-H1069
- Publisher
- United States
- DOI
- 10.1152/ajpheart.00698.2017
- PMID
- 29373045
- PMCID
- PMC6008148
- ISSN
- 0363-6135
- eISSN
- 1522-1539
- Grant note
- P01 HL014388 / NHLBI NIH HHS
- Language
- English
- Date published
- 05/01/2018
- Academic Unit
- Psychological and Brain Sciences; Neuroscience and Pharmacology; Neurology (Pediatrics); Health and Human Physiology
- Record Identifier
- 9984002338202771
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