Journal article
Maternal hyperlipidemia and the risk of preeclampsia: a meta-analysis
American journal of epidemiology, Vol.180(4), pp.346-358
08/15/2014
DOI: 10.1093/aje/kwu145
PMCID: PMC4565654
PMID: 24989239
Abstract
Published reports examining lipid levels during pregnancy and preeclampsia have been inconsistent. The objective of this meta-analysis was to test the association between preeclampsia and maternal total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), non-HDL-C, and triglyceride levels measured during pregnancy. We conducted a systematic search for studies published between the index date until July 2013 reporting maternal lipid levels in women with preeclampsia and normotensive pregnant women. Seventy-four studies met all eligibility criteria and were included in the meta-analysis. Weighted mean differences in lipid levels were calculated using a random-effects model. Statistical heterogeneity was investigated using the I(2) statistic. Meta-regression was used to identify sources of heterogeneity. Preeclampsia was associated with elevated total cholesterol, non-HDL-C, and triglyceride levels, regardless of gestational age at the time of blood sampling, and with lower levels of HDL-C in the third trimester. A marginal association was found with LDL-C levels. Statistical heterogeneity was detected in all analyses. Meta-regression analyses suggested that differences in body mass index (weight (kg)/height (m)(2)) across studies may be partially responsible for the heterogeneity in the triglyceride and LDL-C analyses. This systematic review and meta-analysis demonstrates that women who develop preeclampsia have elevated levels of total cholesterol, non-HDL-C, and triglycerides during all trimesters of pregnancy, as well as lower levels of HDL-C during the third trimester.
Details
- Title: Subtitle
- Maternal hyperlipidemia and the risk of preeclampsia: a meta-analysis
- Creators
- Cassandra N SpracklenCaitlin J SmithAudrey F SaftlasJennifer G RobinsonKelli K Ryckman
- Resource Type
- Journal article
- Publication Details
- American journal of epidemiology, Vol.180(4), pp.346-358
- Publisher
- United States
- DOI
- 10.1093/aje/kwu145
- PMID
- 24989239
- PMCID
- PMC4565654
- ISSN
- 1476-6256
- eISSN
- 1476-6256
- Language
- English
- Date published
- 08/15/2014
- Academic Unit
- Stead Family Department of Pediatrics; Epidemiology; Internal Medicine
- Record Identifier
- 9983996066602771
Metrics
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