Maternal lipid levels during pregnancy and gestational diabetes: a systematic review and meta-analysis

K K Ryckman; C N Spracklen; C J Smith; J G Robinson; A F Saftlas

doi:10.1111/1471-0528.13261

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Maternal lipid levels during pregnancy and gestational diabetes: a systematic review and meta-analysis

Journal article

Peer reviewed

Maternal lipid levels during pregnancy and gestational diabetes: a systematic review and meta-analysis

K K Ryckman, C N Spracklen, C J Smith, J G Robinson and A F Saftlas

BJOG : an international journal of obstetrics and gynaecology, Vol.122(5), pp.643-651

04/2015

DOI: 10.1111/1471-0528.13261

PMID: 25612005

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Abstract

Lipid levels during pregnancy in women with gestational diabetes mellitus (GDM) have been extensively studied; however, it remains unclear whether dyslipidaemia is a potential marker of preexisting insulin resistance. To evaluate the relationship between lipid measures throughout pregnancy and GDM. We searched PubMed-MedLine and SCOPUS (inception until January 2014) and reference lists of relevant studies. Publications describing original data with at least one raw lipid (total cholesterol, high-density lipoprotein cholesterol [HDL-C], low-density lipoprotein cholesterol [LDL-C], or triglyceride) measurement during pregnancy in women with GDM and healthy pregnant controls were retained. Data extracted from 60 studies were pooled and weighted mean difference (WMD) in lipid levels was calculated using random effects models. Meta-regression was also performed to identify sources of heterogeneity. Triglyceride levels were significantly elevated in women with GDM compared with those without GDM (WMD 30.9, 95% confidence interval [95% CI] 25.4-36.4). This finding was consistent in the first, second and third trimesters of pregnancy. HDL-C levels were significantly lower in women with GDM compared with those without GDM in the second (WMD -4.6, 95% CI -6.2 to -3.1) and third (WMD -4.1, 95% CI -6.5 to -1.7) trimesters of pregnancy. There were no differences in aggregate total cholesterol or LDL-C levels between women with GDM and those without insulin resistance. Our meta-analysis shows that triglycerides are significantly elevated among women with GDM compared with women without insulin resistance and this finding persists across all three trimesters of pregnancy.

Pregnancy

Diabetes, Gestational - blood

Diabetes, Gestational - metabolism

Humans

Risk Factors

Insulin Resistance

Mothers

Dyslipidemias - blood

Lipids - blood

Triglycerides - blood

Dyslipidemias - metabolism

Observational Studies as Topic

Female

Pregnancy Trimesters

Details

Title: Subtitle: Maternal lipid levels during pregnancy and gestational diabetes: a systematic review and meta-analysis
Creators: K K Ryckman - Department of Epidemiology, University of Iowa College of Public Health, Iowa City, IA, USA
C N Spracklen
C J Smith
J G Robinson
A F Saftlas
Resource Type: Journal article
Publication Details: BJOG : an international journal of obstetrics and gynaecology, Vol.122(5), pp.643-651
DOI: 10.1111/1471-0528.13261
PMID: 25612005
NLM abbreviation: BJOG
ISSN: 1471-0528
eISSN: 1471-0528
Publisher: England
Language: English
Date published: 04/2015
Academic Unit: Stead Family Department of Pediatrics; Epidemiology; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
Record Identifier: 9983996056702771

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299 Times Cited - Web of Science