Maternal medication and herbal use and risk for hypospadias: data from the National Birth Defects Prevention Study, 1997–2007

Jennifer N Lind; Sarah C Tinker; Cheryl S Broussard; Jennita Reefhuis; Suzan L Carmichael; Margaret A Honein; Richard S Olney; Samantha E Parker; Martha M Werler; National Birth Defects Prevention Study

doi:10.1002/pds.3448

Back

Maternal medication and herbal use and risk for hypospadias: data from the National Birth Defects Prevention Study, 1997–2007

Journal article

Peer reviewed

Maternal medication and herbal use and risk for hypospadias: data from the National Birth Defects Prevention Study, 1997–2007

Jennifer N Lind, Sarah C Tinker, Cheryl S Broussard, Jennita Reefhuis, Suzan L Carmichael, Margaret A Honein, Richard S Olney, Samantha E Parker, Martha M Werler and National Birth Defects Prevention Study

Pharmacoepidemiology and drug safety, Vol.22(7), pp.783-793

07/2013

DOI: 10.1002/pds.3448

PMCID: PMC4037128

PMID: 23620412

Files and links (1)

url

https://www.ncbi.nlm.nih.gov/pmc/articles/4037128View

Open Access

Abstract

ABSTRACT Purpose To investigate associations between maternal use of common medications and herbals during early pregnancy and risk for hypospadias in male infants. Methods We used data from the National Birth Defects Prevention Study, a multi‐site, population‐based, case–control study. We analyzed data from 1537 infants with second‐degree or third‐degree isolated hypospadias and 4314 live‐born male control infants without major birth defects, with estimated dates of delivery from 1997 to 2007. Exposure was reported use of prescription or over‐the‐counter medications or herbal products, from 1 month before to 4 months after conception. Adjusted odds ratios (aORs) and 95% confidence intervals (CIs) were estimated using multivariable logistic regression, adjusting for maternal age, race/ethnicity, education, pre‐pregnancy body mass index, previous live births, maternal subfertility, study site, and year. Results We assessed 64 medication and 24 herbal components. Maternal uses of most components were not associated with an increased risk of hypospadias. A new associations was observed for venlafaxine (aOR 2.4; 95%CI 1.0, 6.0) [Correction made here after initial online publication.]. The previously reported association for clomiphene citrate was confirmed (aOR 1.9; 95%CI 1.2, 3.0). Numbers were relatively small for exposure to other specific patterns of fertility agents, but elevated aORs were observed for the most common of them. Conclusions Overall, findings were reassuring that hypospadias is not associated with most medication components examined in this analysis. New associations will need to be confirmed in other studies. Increased risks for hypospadias associated with various fertility agents raise the possibility of confounding by underlying subfertility. Copyright © 2013 John Wiley & Sons, Ltd.

Pregnancy

birth defects

drug safety

herbal

hypospadias

medication

pharmacoepidemiology

Details

Title: Subtitle: Maternal medication and herbal use and risk for hypospadias: data from the National Birth Defects Prevention Study, 1997–2007
Creators: Jennifer N Lind - Centers for Disease Control and Prevention
Sarah C Tinker - Centers for Disease Control and Prevention
Cheryl S Broussard - Centers for Disease Control and Prevention
Jennita Reefhuis - Centers for Disease Control and Prevention
Suzan L Carmichael - Stanford University
Margaret A Honein - Centers for Disease Control and Prevention
Richard S Olney - Centers for Disease Control and Prevention
Samantha E Parker - Slone Epidemiology Center at Boston University
Martha M Werler - Slone Epidemiology Center at Boston University
National Birth Defects Prevention Study
Contributors: Paul A Romitti (Contributor) - University of Iowa, Epidemiology
Resource Type: Journal article
Publication Details: Pharmacoepidemiology and drug safety, Vol.22(7), pp.783-793
DOI: 10.1002/pds.3448
PMID: 23620412
PMCID: PMC4037128
NLM abbreviation: Pharmacoepidemiol Drug Saf
ISSN: 1053-8569
eISSN: 1099-1557
Number of pages: 11
Language: English
Date published: 07/2013
Academic Unit: Epidemiology; Biostatistics
Record Identifier: 9984214688102771

Metrics

16 Record Views

36 Times Cited - Web of Science