Journal article
Maternal micronutrient deficiency leads to alteration in the kidney proteome in rat pups
Journal of proteomics, Vol.127(Pt A), pp.178-184
09/08/2015
DOI: 10.1016/j.jprot.2015.04.035
PMID: 25982389
Abstract
Maternal nutritional deficiency significantly perturbs the offspring's physiology predisposing them to metabolic diseases during adulthood. Vitamin B12 and folate are two such micronutrients, whose deficiency leads to elevated homocysteine levels. We earlier generated B12 and/or folate deficient rat models and using high-throughput proteomic approach, showed that maternal vitamin B12 deficiency modulates carbohydrate and lipid metabolism in the liver of pups through regulation of PPAR signaling pathway. In this study, using similar approach, we identified 26 differentially expressed proteins in the kidney of pups born to mothers fed with vitamin B12 deficient diet while only four proteins were identified in the folate deficient group. Importantly, proteins like calreticulin, cofilin 1 and nucleoside diphosphate kinase B that are involved in the functioning of the kidney were upregulated in B12 deficient group. Our results hint towards a larger effect of vitamin B12 deficiency compared to that of folate presumably due to greater elevation of homocysteine in vitamin B12 deficient group. In view of widespread vitamin B12 and folate deficiency and its association with several diseases like anemia, cardiovascular and renal diseases, our results may have large implications for kidney diseases in populations deficient in vitamin B12 especially in vegetarians and the elderly people.This article is part of a Special Issue entitled: Proteomics in India.
Details
- Title: Subtitle
- Maternal micronutrient deficiency leads to alteration in the kidney proteome in rat pups
- Creators
- Shadab Ahmad - Institute of Genomics and Integrative BiologyTrayambak Basak - Institute of Genomics and Integrative BiologyK. Anand Kumar - National Institute of Nutrition, Hyderabad, IndiaGourav Bhardwaj - Institute of Genomics and Integrative BiologyA Lalitha - National Institute of NutritionDilip K Yadav - Centre for Cellular and Molecular BiologyGiriraj Ratan Chandak - Centre for Cellular and Molecular BiologyManchala Raghunath - National Institute of NutritionShantanu Sengupta - Academy of Scientific and Innovative Research
- Resource Type
- Journal article
- Publication Details
- Journal of proteomics, Vol.127(Pt A), pp.178-184
- DOI
- 10.1016/j.jprot.2015.04.035
- PMID
- 25982389
- ISSN
- 1874-3919
- eISSN
- 1876-7737
- Grant note
- DOI: 10.13039/501100001332, name: CSIR; DOI: 10.13039/501100002855, name: Ministry of Science and Technology; name: Govt of India, award: BSC0118
- Language
- English
- Date published
- 09/08/2015
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984359761802771
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