Journal article
Maternal microvascular dysfunction during preeclamptic pregnancy
Clinical science (1979), Vol.135(9), pp.1083-1101
05/01/2021
DOI: 10.1042/CS20200894
PMCID: PMC8214810
PMID: 33960392
Abstract
Preeclampsia is a hypertensive disorder of pregnancy effecting -5-8% of pregnancies in the United States, and -8 million pregnancies worldwide. Preeclampsia is clinically diagnosed after the 20th week of gestation and is characterized by new onset hypertension accompanied by proteinuria and/or thrombocytopenia, renal insufficiency, impaired liver function, pulmonary edema, or cerebral or visual symptoms. This broad definition emphasizes the heterogeneity of the clinical presentation of preeclampsia, but also underscores the role of the microvascular beds, specifically the renal, cerebral, and hepatic circulations, in the pathophysiology of the disease. While the diagnostic criteria for preeclampsia relies on the development of de novo hypertension and accompanying clinical symptoms after 20-week gestation, it is likely that subclinical dysfunction of the maternal microvascular beds occurs in parallel and may even precede the development of overt cardiovascular symptoms in these women. However, little is known about the physiology of the non-reproductive maternal microvascular beds during preeclampsia, and the mechanism(s) mediating microvascular dysfunction during preeclamptic pregnancy are largely unexplored in humans despite their integral role in the pathophysiology of the disease. Therefore, the purpose of this review is to provide a summary of the existing literature on maternal microvascular dysfunction during preeclamptic pregnancy by reviewing the functional evidence in humans, highlighting potential mechanisms, and providing recommendations for future work in this area.
Details
- Title: Subtitle
- Maternal microvascular dysfunction during preeclamptic pregnancy
- Creators
- Anna E. Stanhewicz - University of IowaVirginia R. Nuckols - University of IowaGary L. Pierce - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Clinical science (1979), Vol.135(9), pp.1083-1101
- DOI
- 10.1042/CS20200894
- PMID
- 33960392
- PMCID
- PMC8214810
- NLM abbreviation
- Clin Sci (Lond)
- ISSN
- 0143-5221
- eISSN
- 1470-8736
- Publisher
- Portland Press Ltd
- Number of pages
- 19
- Grant note
- University of Iowa Graduate College Diversity Fellowship 18SCG34350001; 15SFRN23760002; 19TPA34910016 / American Heart Association R00HL138133; AG063790 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Language
- English
- Date published
- 05/01/2021
- Academic Unit
- Fraternal Order of Eagles Diabetes Research Center; Health, Sport, and Human Physiology ; Internal Medicine
- Record Identifier
- 9984259403002771
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