Maternal nutrition and gastroschisis: findings from the National Birth Defects Prevention Study

Marcia L Feldkamp; Suzan L Carmichael; Gary M Shaw; Janice D Panichello; Cynthia A Moore; Lorenzo D Botto

doi:10.1016/j.ajog.2010.12.053

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Maternal nutrition and gastroschisis: findings from the National Birth Defects Prevention Study

Journal article

Peer reviewed

Maternal nutrition and gastroschisis: findings from the National Birth Defects Prevention Study

Marcia L Feldkamp, Suzan L Carmichael, Gary M Shaw, Janice D Panichello, Cynthia A Moore and Lorenzo D Botto

American journal of obstetrics and gynecology, Vol.204(5), pp.404.e1-404.e10

2011

DOI: 10.1016/j.ajog.2010.12.053

PMID: 21396620

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Abstract

Gastroschisis is increasing in many countries, especially among young women. Because young women may have inadequate nutrition, we assessed the relationship between individual nutrients and the risk for gastroschisis. We analyzed data from the National Birth Defects Prevention Study, a population-based case-control study. Cases were ascertained from 10 birth defect surveillance systems. Controls were randomly selected from birth certificates or hospital records. Nutrient intake was estimated for the year prior to conception from maternal interviews based on a 58-item food frequency questionnaire and cereal consumption reported. A total of 694 cases and 6157 controls were available for analysis. Reported intake of individual nutrients did not substantially affect the risk for gastroschisis. Stratification by maternal age, preconception body mass index, folic acid–containing supplements, or energy intake (kilocalories) did not alter risk estimates. This study does not support an increased risk for gastroschisis with decreasing tertiles of individual nutrients.

Epidemiology

case-control study

gastroschisis

nutrients

nutrition

Details

Title: Subtitle: Maternal nutrition and gastroschisis: findings from the National Birth Defects Prevention Study
Creators: Marcia L Feldkamp - Division of Medical Genetics, Department of Pediatrics, University of Utah, and the Utah Birth Defect Network, Utah Department of Health, Salt Lake City, UT
Suzan L Carmichael - Division of Neonatology, Department of Pediatrics, Stanford University School of Medicine, Palo Alto, CA
Gary M Shaw - Division of Neonatology, Department of Pediatrics, Stanford University School of Medicine, Palo Alto, CA
Janice D Panichello - Division of Medical Genetics, Department of Pediatrics, University of Utah, and the Utah Birth Defect Network, Utah Department of Health, Salt Lake City, UT
Cynthia A Moore - National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA
Lorenzo D Botto - Division of Medical Genetics, Department of Pediatrics, University of Utah, and the Utah Birth Defect Network, Utah Department of Health, Salt Lake City, UT
Contributors: Paul A Romitti (Contributor) - University of Iowa, Epidemiology
National Birth Defects Prevention Study
Resource Type: Journal article
Publication Details: American journal of obstetrics and gynecology, Vol.204(5), pp.404.e1-404.e10
DOI: 10.1016/j.ajog.2010.12.053
PMID: 21396620
NLM abbreviation: Am J Obstet Gynecol
ISSN: 0002-9378
eISSN: 1097-6868
Publisher: Mosby, Inc
Grant note: U50/CCU822097 / Centers for Disease Control and Prevention DK56350 / Nutrition Epidemiology Core of the University of North Carolina Clinical Nutrition Research Center
Language: English
Date published: 2011
Academic Unit: Epidemiology; Biostatistics
Record Identifier: 9984214724802771

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