Maternal occupational exposure to polycyclic aromatic hydrocarbons and small for gestational age offspring

Peter H Langlois; Adrienne T Hoyt; Tania A Desrosiers; Philip J Lupo; Christina C Lawson; Martha A Waters; Carissa M Rocheleau; Gary M Shaw; Paul A Romitti; Suzanne M Gilboa; Sadia Malik; National Birth Defects Prevention Study

doi:10.1136/oemed-2013-101833

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Maternal occupational exposure to polycyclic aromatic hydrocarbons and small for gestational age offspring

Journal article

Peer reviewed

Maternal occupational exposure to polycyclic aromatic hydrocarbons and small for gestational age offspring

Peter H Langlois, Adrienne T Hoyt, Tania A Desrosiers, Philip J Lupo, Christina C Lawson, Martha A Waters, Carissa M Rocheleau, Gary M Shaw, Paul A Romitti, Suzanne M Gilboa, …

Occupational and environmental medicine (London, England), Vol.71(8), pp.529-535

08/2014

DOI: 10.1136/oemed-2013-101833

PMCID: PMC4497781

PMID: 24893704

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Abstract

While some of the highest maternal exposures to polycyclic aromatic hydrocarbons (PAHs) occur in the workplace, there is only one previous study of occupational PAH exposure and adverse pregnancy outcomes. We sought to extend this literature using interview data combined with detailed exposure assessment. Data for 1997-2002 were analysed from mothers of infants without major birth defects in the National Birth Defects Prevention Study, a large population-based case-control study in the USA. Maternal telephone interviews yielded information on jobs held in the month before conception through delivery. From 6252 eligible control mothers, 2803 completed the interview, had a job, met other selection criteria, and were included in the analysis. Two industrial hygienists independently assessed occupational exposure to PAHs from the interview and reviewed results with a third to reach consensus. Small for gestational age (SGA) was the only adverse pregnancy outcome with enough exposed cases to yield meaningful results. Logistic regression estimated crude and adjusted ORs. Of the 2803 mothers, 221 (7.9%) had infants who were SGA. Occupational PAH exposure was found for 17 (7.7%) of the mothers with SGA offspring and 102 (4.0%) of the remaining mothers. Almost half the jobs with exposure were related to food preparation and serving. After adjustment for maternal age, there was a significant association of occupational exposure with SGA (OR=2.2, 95% CI 1.3 to 3.8). Maternal occupational exposure to PAHs was found to be associated with increased risk of SGA offspring.

Occupational Exposure - adverse effects

Humans

Logistic Models

Gestational Age

Mothers

Case-Control Studies

Pregnancy

Young Adult

Polycyclic Aromatic Hydrocarbons - adverse effects

Maternal Exposure - adverse effects

Adult

Female

Infant, Small for Gestational Age

Odds Ratio

Pregnancy Outcome

Details

Title: Subtitle: Maternal occupational exposure to polycyclic aromatic hydrocarbons and small for gestational age offspring
Creators: Peter H Langlois - Texas Center for Birth Defects Research and Prevention, Birth Defects Epidemiology and Surveillance Branch, Texas Department of State Health Services, Austin, Texas, USA
Adrienne T Hoyt - Texas Center for Birth Defects Research and Prevention, Birth Defects Epidemiology and Surveillance Branch, Texas Department of State Health Services, Austin, Texas, USA
Tania A Desrosiers - Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA
Philip J Lupo - Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA
Christina C Lawson - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio, USA
Martha A Waters - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio, USA
Carissa M Rocheleau - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio, USA
Gary M Shaw - Department of Pediatrics, Stanford University School of Medicine, Palo Alto, California, USA
Paul A Romitti - Department of Epidemiology, College of Public Health, The University of Iowa, Iowa City, Iowa, USA
Suzanne M Gilboa - National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Sadia Malik - Department of Pediatrics, University of Arkansas Medical Sciences, Little Rock, Arkansas, USA
National Birth Defects Prevention Study
Resource Type: Journal article
Publication Details: Occupational and environmental medicine (London, England), Vol.71(8), pp.529-535
DOI: 10.1136/oemed-2013-101833
PMID: 24893704
PMCID: PMC4497781
NLM abbreviation: Occup Environ Med
ISSN: 1470-7926
eISSN: 1470-7926
Publisher: England
Grant note: U01 DD000494 / NCBDD CDC HHS CC999999 / Intramural CDC HHS U01DD000494 / NCBDD CDC HHS U01 DD001035 / NCBDD CDC HHS
Language: English
Date published: 08/2014
Academic Unit: Epidemiology; Biostatistics
Record Identifier: 9983995010102771

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